巨噬细胞对口腔白斑病发展的影响  

Effects of Macrophages on the Development of Oral Leukoplakia

作　　者：贾益群 郑雨燕 JIA Yiqun;ZHENG Yuyan(Stomatology Center,The First Affiliated Hospital,Southern University of Science and Technology//The Second Clinical Medical College,Jinan University//Shenzhen People's Hospital,Shenzhen 518020,China)

机构地区：[1]南方科技大学第一附属医院//暨南大学第二临床医学院//深圳市人民医院口腔医学中心,广东深圳518020

出　　处：《中山大学学报(医学科学版)》2025年第2期245-256,共12页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：深圳市基础研究专项(自然科学基金)(JCYJ20220530152204011);深圳市医学研究专项(A2303027);深圳市医疗卫生三名工程(SZSM202311009)。

摘　　要：口腔白斑病是一种发病率高的潜在恶性黏膜疾患,巨噬细胞在口腔白斑病恶性转化中发挥重要调控作用,但该过程的分子机制研究存在不足。近年研究发现巨噬细胞M2极化对口腔白斑恶性转化具有显著影响,且该过程受到免疫细胞、微生物、细胞因子、细胞外基质等一系列复杂的网络调控。因此本文就巨噬细胞在口腔白斑中的生物学功能、亚型以及其极化的调控因素进行综述,并结合课题组在口腔胞内定植菌与黏膜恶性肿瘤关系的前期研究基础,提出口腔胞内定植菌如牙龈卟啉单胞菌等可能通过促进巨噬细胞M2极化诱导免疫抑制微环境并最终促进白斑恶性转化的机制,从巨噬细胞极化角度探索可能的干预手段,为口腔白斑病及口腔癌的防治提供新的研究方向。Oral leukoplakia is a potentially malignant mucosal disease with a high incidence rate.Macrophages play a significant regulatory role in the malignant transformation of oral leukoplakia,yet there is a lack of research on the molecular mechanisms underlying this process.Recent studies have found that M2 polarization of macrophages has a significant impact on the malignant transformation of oral leukoplakia,and this process is regulated by a complex network involving immune cells,microorganisms,cytokines,and the extracellular matrix,etc.Therefore,this article reviews the biological functions,subtypes,and regulatory factors of macrophage polarization in oral leukoplakia.Building on the preliminary research foundation of our group on the relationship between oral intracellular colonizing bacteria and mucosal malignant tumors,it is proposed that oral intracellular colonizing bacteria,such as Porphyromonas gingivalis,may promote the malignant transformation of leukoplakia by inducing a macrophage M2 polarization that leads to an immunosuppressive microenvironment.This perspective explores potential intervention strategies from the angle of macrophage polarization,providing new research directions for the prevention and treatment of oral leukoplakia and oral cancer.

关 键 词：口腔黏膜病学 巨噬细胞 口腔白斑病 免疫调控 恶性转化 极化 

分 类 号：R780.2[医药卫生—口腔医学] R781.59[医药卫生—临床医学]