Biocompatible copper single-atom site nanozyme for parallel tumor therapy  

作　　者：Haining Zhou Hui Peng Yugui Lian Ting Sun Chang Su Zhiyuan Wang 

机构地区：[1]Department of Gastroenterology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China [2]Department of Radiation Oncology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China [3]Department of Colorectal Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China [4]Department of Clinical Laboratory,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China [5]Center for Clinical Laboratory,General Hospital of the Yangtze River Shipping Wuhan Brain Hospital,Wuhan 430010,China [6]Henan Institute of Advanced Technology,College of Chemistry,Zhengzhou University,Zhengzhou 450001,China

出　　处：《Nano Research》2025年第4期337-345,共9页纳米研究(英文版)

基　　金：supported by the Foundation for Distinguished Young Scholars of medical science and technology innovation in Henan Province(No.YXKC2022033);Fund for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University(No.QNCXTD2023018);Scientific Research Projects of colleges and universities in Henan Province(No.24A320055).

摘　　要：Reasonable design and construction of artificial enzymes with excellent catalytic activity,good stability and superior biocompatibility is essential for tumor therapy.Single-atom site catalysts(SAs)with well-defined atomic structure and electronic coordination environments have been regarded as a new type of nanozyme that can exhibit excellent catalytic activity like natural enzymes.Here,we constructed a copper-based single-atom site nanozyme(named Cu-N,O/C)that stabilized in hollow carbon nanosphere,and the electronic structure of the single copper active center was precisely controlled by regulating the coordination of nitrogen and oxygen.The well-designed Cu-N_(3)O active center enables the Cu-N,O/C nanozyme to exhibit multiple extraordinary enzyme-mimicking activities by synchronously catalyzing the generation of reactive oxygen species(ROS),which can effectively inhibit the growth of tumor cell in vitro and in vivo,and the therapeutic effect pronounced enhanced in the weak acidic tumor environment.In addition,the remarkable near infrared spectroscopy(NIR)-photothermal conversion activity of Cu-N,O/C nanozyme significantly enhances the efficiency of cancer cell killing.Therefore,single-atom site nanozyme possesses significant therapeutic efficacy for tumor therapy through multiple ROS and photothermal activity.

关 键 词：single copper atom catalysts nanozyme reactive oxygen species photothermal therapy TUMOR 

分 类 号：R730.5[医药卫生—肿瘤]