额部脑膜瘤与胶质母细胞瘤碰撞瘤1例并文献复习  

Frontal meningioma colliding glioblastoma:a case report and literature review

作　　者：潘韵松 胡方琪 尹鹏 周辉[1] 施辉 PAN Yunsong;HU Fangqi;YIN Peng;ZHOU Hui;SHI Hui(Department of Neurosurgery,Lianyungang Clinical Medical College,Nanjing Medical University,Lianyungang First People's Hospital,Lianyungang 222000,China)

机构地区：[1]南京医科大学连云港临床医学院,连云港市第一人民医院神经外科,连云港222000 [2]连云港市第二人民医院神经外科

出　　处：《临床神经外科杂志》2025年第2期237-240,共4页Journal of Clinical Neurosurgery

基　　金：连云港市第六期521高层次人才培养工程(LYG06521202104)。

摘　　要：目的 探讨颅内原发性碰撞肿瘤的临床表现、诊断、发病机制及治疗。方法 回顾性分析连云港市第一人民医院神经外科收治的1例颅内原发性碰撞瘤患者临床资料,并复习相关文献。手术采用改良翼点入路切除颅内占位,术后按STUPP方案辅助放化疗。结果 患者因头晕、头痛伴恶心呕吐3 d就诊,MRI显示左侧大脑半球相邻区域存在脑膜瘤和胶质母细胞瘤(GBM)。术后病理证实为脑膜瘤(WHOⅠ级)和GBM(WHOⅣ级),随访8个月时MRI检查示肿瘤原位复发。结论 颅内碰撞瘤多为脑膜瘤与GBM碰撞,临床表现和影像学检查缺乏特异性,病因复杂,涉及遗传、环境、免疫等因素。需进一步研究明确其自然进程和确切机制,探索更有效的治疗策略。Objective To investigate the clinical manifestations,diagnosis,pathogenesis,a nd treatment of primary intracranial collision tumors.Methods The clinical data of one patient with primary intracranial collision tumor treated in the Department of Neurosurgery,Lianyungang First People's Hospital were analyzed retrospectively.The relevant literature were reviewed.The surgery was performed via a modified pterional approach to resect the intracranial mass,and postoperative adjuvant radiochemotherapy was administered according to the STUPP protocol.Results The patient presented with dizziness,headache with nausea and vomiting for 3 days.MRI showed the presence of meningioma and glioblastoma(GBM) in adjacent regions of the left cerebral hemisphere.Postoperative pathology confirmed meningioma(WHO Grade Ⅰ)and GBM(WHO Grade Ⅳ).MRI examination at the 8-month follow-up showed that the tumor recurred at the original site.Conclusions Intracranial collision tumors are often composed of meningioma and GBM.Clinical manifestations and imaging findings lack specificity,and the etiology is complex,involving genetic,environmental,and immunological factors.Further research is needed to clarify their natural course and exact mechanisms and to explore more effective treatment strategies.

关 键 词：脑膜瘤 胶质瘤 碰撞瘤 GBM 

分 类 号：R739.41[医药卫生—肿瘤]