tDCS联合喹硫平治疗青少年首发抑郁症的效果分析  

Effect of tDCS Combined with Quetiapine in the Treatment of Adolescent First-episode Depression

作　　者：严微红 唐小梅 张彦博 YAN Weihong;TANG Xiaomei;ZHANG Yanbo(Department of Psychiatry,the Third People's Hospital of Yichun City,Yichun 336000,China;不详)

机构地区：[1]宜春市第三人民医院精神科,江西宜春336000 [2]宜春市第三人民医院心理科,江西宜春336000

出　　处：《中国医学创新》2025年第10期28-32,共5页Medical Innovation of China

基　　金：宜春市指导性科技计划项目(JXYC2024KSA151)。

摘　　要：目的:探讨经颅直流电刺激(tDCS)联合喹硫平治疗青少年首发抑郁症的效果。方法:选取2023年12月—2024年5月宜春市第三人民医院收治的80例青少年首发抑郁症患者,按随机数字表法分为对照组和研究组,各40例。对照组采用富马酸喹硫平片治疗,研究组在对照组基础上行tDCS治疗。采用抑郁自评量表(SDS)、汉密顿抑郁量表(HAMD)评估患者的抑郁情况;采用症状自评量表(SCL-90)评估患者的精神症状;采用匹兹堡睡眠质量指数(PSQI)评估患者的睡眠质量;比较两组治疗总有效率、不良反应发生率。结果:治疗前,两组SDS、HAMD、SCL-90、PSQI评分比较,差异均无统计学意义(P>0.05);治疗2、4、6、8周后,对照组SDS、HAMD、SCL-90、PSQI评分随治疗周期逐步降低(P<0.05);治疗1、2、4、6、8周后,研究组SDS、HAMD、SCL-90、PSQI评分均随治疗周期逐步降低,且研究组均低于对照组(P<0.05)。研究组总有效率高于对照组(P<0.05)。两组不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:喹硫平联合tDCS治疗青少年首发抑郁症,可以更好地改善患者抑郁情况、精神症状、睡眠质量,且起效更快,不良反应无显著差异,值得临床探讨使用。Objective:To investigate the therapeutic effect of transcranial direct current stimulation(tDCS)combined with Quetiapine on adolescent first-episode depression.Method:A total of 80 adolescent first-episode depression patients admitted to the Third People's Hospital of Yichun City from December 2023 to May 2024 were selected and divided into control group and study group according to random number table method,with 40 cases in each group.The control group was treated with Quetiapine Fumarate Tablets,and the study group was treated with tDCS on the basis of the control group.Self-rating depression scale(SDS)and Hamilton depression scale(HAMD)were used to evaluate the depression status of the patients;symptom self-rating scale(SCL-90)was used to evaluate the mental symptoms of the patients.The sleep quality of patients was assessed by Pittsburgh sleep quality index(PSQI).The total effective rate and incidence of adverse reactions were compared between the two groups.Result:Before treatment,there were no significant differences in SDS,HAMD,SCL-90 and PSQI scores between the two groups(P>0.05).After 2,4,6 and 8 weeks of treatment,the scores of SDS,HAMD,SCL-90,PSQI in the control group were gradually decreased with the treatment cycle(P<0.05).After 1 week,2,4,6 and 8 weeks of treatment,the scores of SDS,HAMD,SCL-90,PSQI in the study group were gradually decreased with the treatment cycle,and the scores in the study group were lower than those in the control group(P<0.05).The total effective rate of the study group was higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Quetiapine combined with tDCS in the treatment of adolescent first-episode depression can better improve the depression,mental symptoms and sleep quality of patients,and the effect is faster,and there is no significant difference in adverse reactions,which is worthy of clinical discussion.

关 键 词：抑郁症 青少年 首发 经颅直流电刺激 喹硫平 

分 类 号：R749.4[医药卫生—神经病学与精神病学]