蛋白质乳酸化修饰在眼科疾病中的研究进展  

Research progress on protein lactylation in ophthalmic diseases

作　　者：陈洪良 索龙 王乾坤 刘爽 Chen Hongliang;Suo Long;Wang Qiankun;Liu Shuang(Department of Ophthalmology,Taicang Loujiang New City Hospital,Taicang 215400,Jiangsu Province,China;Jiangsu Province(Suqian)Hospital,Suqian First Hospital,Nanjing Medical University,Suqian 223800,Jiangsu Province,China)

机构地区：[1]江苏省太仓市娄江新城医院眼科,215400 [2]江苏省人民医院宿迁医院南京医科大学附属宿迁第一人民医院,江苏省宿迁市223800

出　　处：《国际眼科杂志》2025年第5期797-801,共5页International Eye Science

基　　金：宿迁市自然科学基金项目(No.K202312);宿迁市第一人民医院科研专项(No.KY202317);南京医科大学科技发展基金项目(No.NMUB20220215)。

摘　　要：乳酸化修饰是最新发现的一种由乳酸诱导的蛋白质翻译后修饰,在组蛋白和非组蛋白的赖氨酸残基的多个位点上均可发生。乳酸化修饰通过影响转录调控、线粒体代谢、免疫炎症等机制参与疾病发生。乳酸化修饰在不同眼科疾病中的作用机制研究也取得许多创新性进展,如视网膜新生血管性疾病、葡萄膜炎、黑色素瘤和近视等。文章就乳酸和乳酸化的联系、乳酸化的调控机制以及乳酸化在不同眼科疾病中的作用展开综述。同时总结了目前的研究局限性和未来的发展方向,对阐明乳酸化修饰在眼病中的潜在分子机制以及相关疾病的诊断和精准治疗具有重要意义。Lactylation,a recently identified post-translational modification of proteins,is induced by lactic acid and can occur at multiple lysine residues in both histone and non-histone proteins.This modification plays a role in disease pathogenesis by affecting transcriptional regulation,mitochondrial metabolism,and immune inflammation.Significant advancements have been made in understanding the mechanisms of lactylation in various ophthalmic diseases,including retinal neovascularization,uveitis,melanoma,and myopia.This paper provides a comprehensive review of the relationship between lactic acid and lactylation,the regulatory mechanisms of lactylation,and the role of lactylation in different ocular diseases.Additionally,it addresses current research limitations and future directions,which is of great significance to elucidate the molecular mechanisms of lactylation in eye diseases and improving the diagnosis and targeted treatment of these conditions.

关 键 词：乳酸 乳酸化 糖酵解 翻译后修饰 眼科疾病 

分 类 号：R77[医药卫生—眼科]