Early detection of Alzheimer's disease using the MEMORIES mnemonic  

作　　者：Valentinus Besin Farizky M.Humardani 

机构地区：[1]Faculty of Medicine,University of Surabaya,Surabaya,Indonesia [2]Doctoral Study Program in Medical Science,Faculty of Medicine Universitas Brawijaya,Malang,Indonesia [3]Bioinformatics Research Center,Indonesian Bioinformatics and Biomolecular,Malang,Indonesia

出　　处：《Chronic Diseases and Translational Medicine》2025年第1期22-32,共11页慢性疾病与转化医学(英文版)

摘　　要：The rising incidence and death rates linked to Alzheimer's disease(AD)highlight an urgent issue.Genetic screening is celebrated as a significant advancement for its early detection capabilities,pinpointing those at risk before the emergence of symptoms.Yet,the limited availability of these technologies highlights a critical gap in widespread application.This review pivots to the potential of presymptomatic clinical assessments as a readily available,economical,and simple strategy for early detection.Traditionally,AD diagnosis relies on the late-stage identification of cognitive deterioration,functional impairments,and neuropsychiatric symptoms,coinciding with advanced brain degeneration.Conversely,emerging research identifies early indicators preceding significant degeneration,manifesting years before clinical symptoms.We introduce a mnemonic,MEMORIES,to categorize these prodromal:Metabolism changes,Eye/visual impairments,March(refer to gait disturbances),Olfactory dysfunction,Rhythm(blood pressure and heart rate),Insensitivity of the tongue,Ears(hearing loss),and Stool alterations.Recognizing these prodromal through clinical examinations provides a valuable strategy for initiating preventative actions against brain degeneration.This approach advocates for broadening the screening lens beyond genetic screening to encompass clinical evaluations,enhancing early detection and intervention opportunities for AD.

关 键 词：Alzheimer's clinical settings PRODROMAL 

分 类 号：R749.1[医药卫生—神经病学与精神病学]