PRODROMAL

作品数：15被引量：16H指数：2
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Correlation of inflammatory markers with depression and sleep disorders accompanying the prodromal stage of Parkinson’s disease
《World Journal of Psychiatry》2025年第3期49-57,共9页Cheng-Guang Zhang Yu Zhang Ke Xu Shun Wang Yan Bai 
Parkinson’s disease(PD)is a common neurodegenerative disorder with increasing incidence and disability rates globally,placing a heavy burden on patients and their families.In the prodromal phase of PD,nonmotor sympto...
关键词：Parkinson's disease Prodromal Parkinson's disease Inflammatory markers DEPRESSION Sleep disorders 
DOPA-decarboxylase is elevated in CSF,but not plasma,in prodromal and de novo Parkinson’s disease
《Translational Neurodegeneration》2024年第1期692-695,共4页Ellen Appleton Shervin Khosousi Michael Ta Michael Nalls Andrew B.Singleton Andrea Sturchio Ioanna Markaki Wojciech Paslawski Hirotaka Iwaki Per Svenningsson 
supported in part by the Intramural Research Program of the National Institute on Aging(NIA),the Center for Alzheimer’s and Related Dementias(CARD),within the Intramural Research Program of the National Institute on Aging and the National Institute of Neurological Disorders and Stroke(AG000546).
Parkinson’s disease(PD)diagnosis is based solely on clinical presentation[1].Therefore,diagnostic and prog-nostic biomarkers are needed.In recent years,seeding aggregation assays(SAA)have demonstrated the ability to ...
关键词：ELEVATED diagnosis clinical 
Consensus on rapid screening for prodromal Alzheimer's disease in China被引量：2
《General Psychiatry》2024年第1期1-16,共16页Lin Huang Qinjie Li Yao Lu Fengfeng Pan Liang Cui Ying Wang Ya Miao Tianlu Chen Yatian Li Jingnan Wu Xiaochun Chen Jianping Jia Qihao Guo 
the National Natural Science Foundation of China(82171198,U20A20354);the Sci-Tech Innovation 2030 Agenda of China(2022ZD0211603).
Alzheimer's disease(AD)is a common cause of dementia,characterised by cerebral amyloid-βdeposition,pathological tau and neurodegeneration.The prodromal stage of AD(pAD)refers to patients with mild cognitive impairmen...
关键词：ALZHEIMER INCOME SCREENING 
Investigation of prodromal features in metabolic syndrome based on transcriptome analysis被引量：1
《Genes & Diseases》2023年第3期708-711,共4页Sang-Min Park Musun Park Hyo-Jeong Ban Su-Jin Baek Soo Yeon Kim Siwoo Lee Hee-Jeong Jin 
supported by the“Development of Korean Medicine Original Technology for Preventive Treatment based on Integrative Big Data”grant from the Korea Institute of Oriental Medicine(No.KSN2023120).
Metabolic syndrome(MetS)is a complex condition that significantly increases the risk of several diseases,including heart disease and diabetes.Patients with MetS show both pro-inflammatory and pro-thrombotic states;how...
关键词：DISEASES METABOLIC PATIENTS 
Prodromal Parkinson’s disease: hype or hope for disease-modification trials?被引量：4
《Translational Neurodegeneration》2022年第1期777-789,共13页Philipp Mahlknecht Kathrin Marini Mario Werkmann Werner Poewe Klaus Seppi 
There was no specific funding for this article.P.M.:reports lecture fees from Boston Scientific outside the submitted work and a grant from the Tiroler Wissenschaftsförderung(Grant UNI-0404/2245);K.M.:has been supported by a grant from the Tiroler Wissenschaftsförderung(Grant UNI-0404/2245);M.W.:Nothing to report.W.P.:reports personal fees from Alterity,AbbVie,Affiris,AstraZeneca,BIAL,Biogen,Britannia,Lilly,Lundbeck,Neuroderm,Neurocrine,Denali Pharmaceuticals,Novartis,Orion Pharma,Roche,Takeda,Teva,UCB,and Zambon(consultancy and lecture fees in relation to clinical drug development programs for PD);royalties from Thieme,Wiley Blackwell,Oxford University Press,and Cambridge University Press;and grant support from MJFF;EU FP7,and Horizon 2020 outside the submitted work.K.S.:reports personal fees from Teva,UCB,Lundbeck,AOP Orphan Pharmaceuticals AG,Roche,Grünenthal,Stada,Licher Pharma,Biogen,and Abbvie;honoraria from the International Parkinson and Movement Disorders Society;and research grants from FWF Austrian Science Fund,Michael J.Fox Foundation,and AOP Orphan Pharmaceuticals AG,outside the submitted work.
The ultimate goal in Parkinson’s disease (PD) research remains the identification of treatments that are capable of slowing or even halting the progression of the disease. The failure of numerous past disease-modific...
关键词：NEUROPROTECTION PRECLINICAL Prevention Epidemiology Probability Randomized controlled trial PREVENTIVE NEUROPROTECTIVE 
Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer’s disease mice被引量：4
《Translational Neurodegeneration》2020年第2期203-213,共11页Peng-Hui Ai Si Chen Xian-Dong Liu Xiao-Na Zhu Yuan-Bo Pan Dong-Fu Feng Shengdi Chen Nan-Jie Xu Suya Sun 
This research was supported by the National Natural Science Foundation of China(81870820 and 31671062 to N.-J.X.,81671047 to S.S.);Grants of Shanghai Brain-Intelligence Project from STCSM(16JC1420500);the Science and Technology Commission of Shanghai Municipality(18JC1420302);Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-01-E00046).
Background Neuropsychiatric symptoms(NPS)such as depression,anxiety,apathy,and irritability occur in prodromal phases of clinical Alzheimer’s disease(AD),which might be an increased risk for later developing AD.Here ...
关键词：Alzheimer's disease Paroxetine treatment Glutamate receptor Memory deficit 
Investigation of the incidences of non-mo-tor symptoms in siblings and spouses of patients withParkinson's disease
《China Medical Abstracts(Internal Medicine)》2018年第4期237-238,共2页LIU Jiangbing 
Objective Non-motor symptoms are important prodromal characteristics of Parkinson's disease(PD).The siblings and the spouses of PD patients do not have classic motor symptoms.This study aimed to investigate if they ha...
关键词：NON-MOTOR SYMPTOMS important PRODROMAL characteristics 
Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease被引量：1
《Translational Neurodegeneration》2018年第1期244-260,共17页Haichen Niu Lingyu Shen Tongzhou Li Chao Ren Sheng Ding Lei Wang Zhonghai Zhang Xiaoyu Liu Qiang Zhang Deqin Geng Xiujuan Wu Haiying Li 
Scientific Research Foundation of China supported this work(No.53631305);Xuzhou city(social development)project(No.KC15SM048);NSFC(81471330,81560168,81470684)and the Qing Lan Project.
Background:Parkinson’s disease(PD)is a neurodegenerative disease characterized by intraneuronal Lewy Body(LB)aggregates composed of misfolded alpha-synuclein(α-syn).The spread of misfoldedα-syn follows a typical pa...
关键词：ALPHA-SYNUCLEIN PRODROMAL animal model Parkinson’s disease OLFACTORY BULB Autophagy 
The underlying mechanism of prodromal PD:insights from the parasympathetic nervous system and the olfactory system被引量：2
《Translational Neurodegeneration》2017年第1期20-28,共9页Shu-Ying Liu Piu Chan A.Jon Stoessl 
Neurodegeneration of Parkinson’s disease(PD)starts in an insidious manner,30–50%of dopaminergic neurons have been lost in the substantia nigra before clinical diagnosis.Prodromal stage of the disease,during which th...
关键词：Parkinson’s disease PRODROMAL ALPHA-SYNUCLEIN Parasympathetic nervous system Olfactory system SUBTYPE 
Episodic Learning and Memory in Prodromal Huntington’s Disease: The Role of Multimodal Encoding and Selective Reminding
《International Journal of Clinical Medicine》2015年第11期876-886,共11页Tarja-Brita Robins Wahlin Ake Wahlin Gerard JByrne 
Department of Clinical Genetics, Karolinska University Hospital
This study investigated episodic memory in prodromal HD. Three groups were compared (N = 70): mutation carriers with less than 12.5 years to disease onset (n = 16), mutation carriers with 12.5 or more years to disease...
关键词：Prodromal Huntington’s Disease Fuld Object Memory Evaluation Episodic Memory Short-Term Memory Neurodegenerative Diseases 
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