30岁以下年轻肺癌患者临床特征的回顾性研究  

Retrospective Study on Clinical Characteristics of Lung Cancer in Young Adults Aged<30 Years

作　　者：王善钻[1] WANG Shanzuan(Department of Geriatric Medicine,The Affiliated Hospital of Putian University,Putian Fujian 351100,China)

机构地区：[1]莆田学院附属医院老年医学科,福建莆田351100

出　　处：《莆田学院学报》2025年第2期36-40,共5页Journal of putian University

基　　金：莆田市医疗卫生领域科技创新联合资金项目(2024SJYL045)。

摘　　要：对莆田学院附属医院收治的139例30岁以下年轻肺癌患者情况进行回顾分析。纳入研究的患者,女性91例(65.5%);10例患者有吸烟史(7.2%);腺癌是最常见的组织学类型(93.5%);诊断时最常见的分期为Ⅰ期(61.2%)和Ⅳ期(30.2%);临床仅对34例患者进行了基因检测,23例检出基因突变阳性;间变性淋巴瘤激酶(ALK)重排是最常见的基因突变类型。研究发现:30岁以下年轻肺癌患者以女性、无吸烟史、腺癌为主。基因突变(尤其是ALK重排)的患者具有更高的疾病分期。A retrospective analysis was conducted on 139 young lung cancer patients under the age of 30 who were treated at the Affiliated Hospital of Putian University.Among the patients included in the study,91 were female(65.5%),10 patients had a history of smoking(7.2%).Adenocarcinoma was the most common histological type(93.5%).The most common stages at diagnosis were stage Ⅰ(61.2%)and stageⅣ(30.2%).Genetic testing were performed on only 34 patients,with 23 testing positive for gene mutations.Anaplastic Lymphoma Kinase(ALK)rearrangement was the most common type of gene mutation.The study found that young lung cancer patients under the age of 30 were predominantly female,non-smokers,and had adenocarcinoma.Patients with gene mutations(especially ALK rearrangement)had a higher disease stage.

关 键 词：肺癌 基因突变 危险因素 生存分析 

分 类 号：R734[医药卫生—肿瘤]