Memory Reconsolidation Updating in Substance Addiction: Applications, Mechanisms, and Future Prospects for Clinical Therapeutics  

作　　者：Shihao Huang Xiaoxing Liu Zhonghao Li Yue Si Liping Yang Jiahui Deng Yixiao Luo Yan-Xue Xue Lin Lu 

机构地区：[1]Department of Neurobiology,School of Basic Medical Sciences,National Institute on Drug Dependence,Peking University,Beijing,100191,China [2]Beijing Key Laboratory of Drug Dependence Research,Peking University,Beijing,100191,China [3]Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Peking University,Beijing,100191,China [4]Department of Anesthesiology,The Second Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,421001,China [5]Chinese Institute for Brain Research,Beijing,102206,China [6]Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research,Peking University,Beijing,100871,China

出　　处：《Neuroscience Bulletin》2025年第2期289-304,共16页神经科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(82071498,81871046,and 32161143022);STI2030-Major Projects(2022ZD0214500).

摘　　要：Persistent and maladaptive drug-related memories represent a key component in drug addiction.Converging evidence from both preclinical and clinical studies has demonstrated the potential efficacy of the memory reconsolidation updating procedure(MRUP),a non-pharmacological strategy intertwining two distinct memory processes:reconsolidation and extinction—alternatively termed“the memory retrieval-extinction procedure”.This procedure presents a promising approach to attenuate,if not erase,entrenched drug memories and prevent relapse.The present review delineates the applications,molecular underpinnings,and operational boundaries of MRUP in the context of various forms of substance dependence.Furthermore,we critically examine the methodological limitations of MRUP,postulating potential refinement to optimize its therapeutic efficacy.In addition,we also look at the potential integration of MRUP and neurostimulation treatments in the domain of substance addiction.Overall,existing studies underscore the significant potential of MRUP,suggesting that interventions predicated on it could herald a promising avenue to enhance clinical outcomes in substance addiction therapy.

关 键 词：RECONSOLIDATION EXTINCTION Memory reconsolidation updating Retrieval-extinction Drug addiction 

分 类 号：R749.6[医药卫生—神经病学与精神病学]