Neurodegenerative Diseases:What Can Be Learned from Toothed Whales?  

作　　者：Simona Sacchini 

机构地区：[1]Department of Morphology,Universidad de Las Palmas de Gran Canaria(ULPGC),Campus Universitario de San Cristóbal,c/Blas Cabrera Felipe s/n,35016,Las Palmas de Gran Canaria,Spain

出　　处：《Neuroscience Bulletin》2025年第2期326-338,共13页神经科学通报(英文版)

基　　金：Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature.

摘　　要：Neurodegeneration involves a wide range of neuropathological alterations affecting the integrity,physiology,and architecture of neural cells.Many studies have demonstrated neurodegeneration in different animals.In the case of Alzheimer's disease(AD),spontaneous animal models should display two neurohistopathological hallmarks:the deposition ofβ-amyloid and the arrangement of neurofibrillary tangles.However,no natural animal models that fulfill these conditions have been reported and most research into AD has been performed using transgenic rodents.Recent studies have also demonstrated that toothed whales-homeothermic,long-lived,top predatory marine mammals-show neuropathological signs of AD-like pathology.The neuropathological hallmarks in these cetaceans could help to better understand their endangered health as well as neurodegenerative diseases in humans.This systematic review analyzes all the literature published to date on this trending topic and the proposed causes for neurodegeneration in these iconic marine mammals are approached in the context of One Health/Planetary Health and translational medicine.

关 键 词：Neurodegenerative diseases NEURODEGENERATION Alzheimer’s disease Amyloidβ Natural animal models CETACEANS Toothed whales 

分 类 号：R741[医药卫生—神经病学与精神病学]