Intra-tumoral bacteria in head and neck cancer:holistic integrative insight  

作　　者：Yucheng Meng Jiaru Deng Weiwei Deng Zhijun Sun 

机构地区：[1]State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School&Hospital of Stomatology,Frontier Science Center for Immunology and Metabolism,Taikang Center for Life and Medical Sciences,Wuhan University,Wuhan 430079,China [2]Department of Oral&Maxillofacial Head Neck Oncology,School&Hospital of Stomatology,Wuhan University,Wuhan 430079,China

出　　处：《Cancer Biology & Medicine》2025年第2期113-136,共24页癌症生物学与医学(英文版)

基　　金：supported by grants from the National Natural Science Foundation of China(Grant nos.82472818 and 82103336);the Fundamental Research Funds for the Central Universities(Grant nos.2042024kf0021 and 2042022dx0003);the Natural Science Foundation of Wuhan(Grant no.2023020201020515)。

摘　　要：Intra-tumoral bacteria are pivotal in the initiation and progression of head and neck squamous cell carcinoma(HNSCC),exerting a significant influence on tumor cell biology,immune responses,and the tumor microenvironment(TME).Different types and distribution of bacteria threaten the balance of metabolism and the immune environment of tumor cells.Taking advantage of this disrupted homeostasis,intra-tumoral bacteria stimulate the secretion of metabolites or influence specific immune cell types to produce inflammatory or chemokines,thereby influencing the anti-tumor immune response while regulating the level of inflammation and immunosuppression within the TME.Some intra-tumoral bacteria are used as diagnostic and prognostic markers in clinical practice.Based on the unique characteristics of bacteria,the use of engineered bacteria and outer membrane vesicles for drug delivery and biological intervention is a promising new therapeutic strategy.The presence of intra-tumoral bacteria also makes chemoradiotherapy tolerable,resulting in a poor treatment effect.However,due to the immune-related complexity of intra-tumoral bacteria,there may be unexpected effects in immunotherapy.In this review the patterns of intra-tumoral bacteria involvement in HNSCC are discussed,elucidating the dual roles,while exploring the relevance to anti-tumor immune responses in the clinical context and the prospects and limitations of the use of bacteria in targeted therapy.

关 键 词：Head and neck squamous cell carcinoma intra-tumoral bacteria tumor progression IMMUNITY therapy 

分 类 号：R739.91[医药卫生—肿瘤]