Regulation and application of m^(6)A modification in tumor immunity  

作　　者：Qunli Xiong Yaguang Zhang Ying Zheng Qing Zhu 

机构地区：[1]Division of Abdominal Tumor Multimodality Treatment,Cancer Center,Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,China [2]Laboratory of Gastrointestinal Tumor Epigenetics and Genomics,Frontiers Science Center for Disease-related Molecular Network,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Science China(Life Sciences)》2025年第4期974-993,共20页中国科学(生命科学英文版)

基　　金：supported by the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21042);the National Natural Science Foundation of China(82203447)。

摘　　要：The m^(6)A modification is an RNA modification that impacts various processes of RNA molecules,including transcription,splicing,stability,and translation.Recently,researchers have discovered that the presence of m^(6)A modification can influence the interaction between tumor cells and immune cells and also play a role in regulating the expression of immune response-related genes.Additionally,m^(6)A modification is intricately involved in the regulation of tumor immune evasion and drug resistance.Specifically,certain tumor cells can manipulate the gene expression through m^(6)A modification to evade immune system attacks.Therefore,it might be possible to enhance tumor immune surveillance and improve the effectiveness of immune-based therapies by manipulating m^(6)A modification.This review systematically discusses the role of m6A modification in tumor immunity,specifically highlighting its regulation of immune cells and immune-related genes in tumor cells.Furthermore,we explore the potential of m6A modification inhibitors as anti-cancer therapies and the significance of m6A regulatory factors in predicting the efficacy of tumor immune therapy.

关 键 词：m^(6)A modification RNA modification tumor immunity immune evasion INHIBITOR THERAPY 

分 类 号：R730.3[医药卫生—肿瘤]