Ketogenic diet and cancer:multidimensional exploration and research  

作　　者：Shiyun Wan Xiaoxue Zhou Feng Xie Fangfang Zhou Long Zhang 

机构地区：[1]The First Affiliated Hospital,the Institutes of Biology and Medical Sciences,Suzhou Medical College,Soochow University,Suzhou 215123,China [2]School of Medicine,Hangzhou City University,Hangzhou 310015,China [3]Life Sciences Institute and State Key Laboratory of Transvascular Implantation Devices of the Second Affiliated Hospital of Zhejiang University School of Medicine,Zhejiang University,Hangzhou 310058,China [4]The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors,The First Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330031,China [5]Cancer Center Zhejiang University,Hangzhou 310058,China

出　　处：《Science China(Life Sciences)》2025年第4期1010-1024,共15页中国科学(生命科学英文版)

基　　金：supported by a special program from the National Key Research and Development Program of China(2021YFA1101000,2022YFA1105200);the National Natural Science Fundation of China(92169122,82473119,32125016,T2321005,U20A201376,U20A20393,31925013);Excellent Youth Fund of Jiangsu Province(BK2024014);Suzhou Innovation and Entrepreneurship Leading Talent Program(ZXL2022442,ZXL2022505);Suzhou Medical College Basic Frontier Innovation Cross Project(YXY2302017,YXY2303027);the Priority Acadamic Program Development of Jiangsu Higher Education Institutions。

摘　　要：The ketogenic diet(KD)has attracted attention in recent years for its potential anticancer effects.KD is a dietary structure of high fat,moderate protein,and extremely low carbohydrate content.Originally introduced as a treatment for epilepsy,KD has been widely applied in weight loss programs and the management of metabolic diseases.Previous studies have shown that KD can potentially inhibit the growth and spread of cancer by limiting energy supply to tumor cells,thereby inhibiting tumor angiogenesis,reducing oxidative stress in normal cells,and affecting cancer cell signaling and other processes.Moreover,KD has been shown to influence T-cell-mediated immune responses and inflammation by modulating the gut microbiota,enhance the efficacy of standard cancer treatments,and mitigate the complications of chemotherapy.However,controversies and uncertainties remain regarding the specific mechanisms and clinical effects of KD as an adjunctive therapy for cancer.Therefore,this review summarizes the existing research and explores the intricate relationships between KD and cancer treatment.

关 键 词：ketogenic diet CANCER METABOLISM IMMUNERESPONSE THERAPY 

分 类 号：R730.5[医药卫生—肿瘤]