Sirtuins在衰老相关口腔疾病中的研究进展  

Research progress on sirtuins in aging-related oral diseases

作　　者：刘宇村曦 吴明松 刘建国 Liu Yucunxi;Wu Mingsong;Liu Jianguo(Department of Conservative Dentistry,School of Stomatology,Special Key Laboratory of Oral Diseases Research,Higher Education Institution in Guizhou province,Zunyi Medical University,Zunyi Guizhou 563006,China;Department of Stomatology,the First Affiliated Hospital of Hunan University of Medicine,Huaihua Hunan 418000,China;Department of Stomatology,School of Medicine&Nursing,Huzhou University,Huzhou Zhejiang 313000,China)

机构地区：[1]遵义医科大学口腔医学院口腔内科学教研室,贵州省普通高等学校口腔疾病研究特色重点实验室,贵州遵义563006 [2]湖南医药学院第一附属医院口腔科,湖南怀化41800 [3]湖州师范学院医学院(护理学院)口腔医学系,浙江湖州313000

出　　处：《遵义医科大学学报》2025年第4期400-407,413,共9页Journal of Zunyi Medical University

基　　金：贵州省科技计划项目[NO:黔科合支撑(2023)一般260];贵州省教育厅滚动支持省属高校科研平台团队项目[NO:黔教技(2022)025]。

摘　　要：目的衰老是指机体生理和心理功能随增龄呈渐进性衰退、逐渐趋向死亡的现象。沉默信息调节因子(sirtuins)家族是一类高度保守地依赖于NAD^(+)的组蛋白去乙酰化酶,参与许多与衰老相关的生物学过程,调节许多与衰老相关的信号通路。随着年龄的增长,牙周炎、口腔癌和根尖周病等口腔疾病的患病率增加,Sirtuins在该过程中起重要的调控作用。本文就Sirtuins家族的一般情况,Sirtuins与衰老相关的重要信号通路和Sirtuins在衰老相关的口腔疾病中的调控作用进展作一综述。Objective Aging is defined as the progressive decline in physiological and psychological functions of an organism with advancing age,ultimately culminating in mortality.The sirtuin family,evolutionarily conserved NAD^(+)-dependent histone deacetylases,has emerged as important players in modulating aging-related biological processes and signaling networks.With aging,the prevalence of oral diseases such as periodontitis,oral cancer,and periapical disease increases,and sirtuins play a critical regulatory role in this context.This review summarized general overview of the sirtuin family,their crosstalk with core aging-associated signaling pathways,and recent advances in sirtuin’regulatory functions in aging-associated oral diseases.

关 键 词：SIRTUINS 衰老 信号通路 牙周炎 口腔癌 根尖周病 

分 类 号：R787[医药卫生—口腔医学]