The subventricular zone structure, functionand implications for neurological disease  

作　　者：Kaishu Li Yin Zheng Shubing Cai Zhiming Fan Junyi Yang Yuanrun Liu Shengqi Liang Meihui Song Siyuan Du Ling Qi 

机构地区：[1]Department of Neurosurgery,The Affiliated Qingyuan Hospital(Qingyuan People’s Hospital),Guangzhou Medical University,Qingyuan,Guangdong 511518,China [2]Institute of Digestive Diseases,The Affiliated Qingyuan Hospital(Qingyuan People’s Hospital),Guangzhou Medical University,Qingyuan,Guangdong 511518,China

出　　处：《Genes & Diseases》2025年第3期122-136,共15页基因与疾病(英文)

基　　金：supported by the Medical Scientific Research Foundation of Guangdong Province,China(No.A2022125,A2023486);the Medical Research Fund of the Qingyuan People’s Hospital(No.15001019002213);the National Natural Science Foundation of China(No.82203351);The Guangdong Basic and Applied Basic Research Foundation of China(No.2021A1515111095).

摘　　要：The subventricular zone (SVZ) is a region surrounding the lateral ventricles thatcontains neural stem cells and neural progenitor cells, which can proliferate and differentiateinto various neural and glial cells. SVZ cells play important roles in neurological diseases likeneurodegeneration, neural injury, and glioblastoma multiforme. Investigating the anatomy,structure, composition, physiology, disease associations, and related mechanisms of SVZ is significant for neural stem cell therapy and treatment/prevention of neurological disorders. However, challenges remain regarding the mechanisms regulating SVZ cell proliferation,differentiation, and migration, delivering cells to damaged areas, and immune responses.In-depth studies of SVZ functions and related therapeutic developments may provide new insights and approaches for treating brain injuries and degenerative diseases, as well as a scientific basis for neural stem cell therapy. This review summarizes research findings on SVZ andneurological diseases to provide references for relevant therapies.

关 键 词：Glioblastoma multiforme Neural injury repair Neural stem cells NEURODEGENERATIVE Subventricular zone 

分 类 号：R741[医药卫生—神经病学与精神病学]