Coding circular RNA in human cancer  

作　　者：Yuan Lin Yawen Wang Lixin Li Kai Zhang 

机构地区：[1]Department of Breast Surgery,General Surgery,Qilu Hospital of Shandong University,Jinan,Shandong 250000,China

出　　处：《Genes & Diseases》2025年第3期194-204,共11页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China(No.81802406);Shandong Provincial Natural Science Foundation of China(No.ZR2021MH045,ZR2020LZL009,ZR2019BH061,ZR2021MH225);Special Funds for Scientific Research on Breast Diseases of Shandong Medical Association of China(No.YXH2021ZX058).

摘　　要：circular RNA (circRNA) is a covalently closed single-stranded RNA that lacks 5’ and 3’ends and has long been considered a noncoding RNA. With the development of high-throughputsequencing and bioinformatics technology, the understanding of circRNA has become increasingly advanced. Recent studies have shown that some cytoplasmic circRNAs can be effectivelytranslated into detectable proteins, further indicating the importance of circRNA in cellular pathology and physiological functions. Internal ribosome entry site (IRES) and N^(6)-methyladenosine(m^(6)A) mediated cap-independent translation initiation are considered potential mechanisms ofcircRNA translation. Multiple circRNAs have been shown to play crucial roles in human cancer.This paper provides an overview of the nature and functions of circRNA and describes thepossible mechanisms underlying the initiation of circRNA translation. We summarized theemerging functions of circRNA-encoded proteins in human cancer. Finally, we discuss the therapeutic potential of circRNAs and the challenges of research in this field. This review on circRNAtranslation will reveal a hidden human proteome and enhance our understanding of the importance of circRNAs in human malignant tumors.

关 键 词：Cancer Cap-independent Circular RNA Protein-coding circRNA TRANSLATION 

分 类 号：R730.2[医药卫生—肿瘤]