《儿童和青少年垂体腺瘤的诊断与治疗共识指南》要点解读  

Key points interpretation of the Consensus Guideline for the Diagnosis and Management of Pituitary Adenomas in Childhood and Adolescence

作　　者：梁小雪 隆敏 LIANG Xiaoxue;LONG Min(Department of Endocrinology,The First Affiliated Hospital of Army Medical University,Chongqing 400037,China)

机构地区：[1]陆军军医大学第一附属医院内分泌科,重庆400037

出　　处：《现代医药卫生》2025年第4期817-821,共5页Journal of Modern Medicine & Health

基　　金：重庆市中青年医学高端人才内分泌垂体性腺疾病工作室资助项目(渝卫人〔2023〕10号)。

摘　　要：垂体腺瘤在儿童和青少年中较为罕见,由于缺乏针对这一年龄群体的高质量证据,其诊断与治疗具有挑战性。除了瘤体本身占位和激素分泌异常特性,包括外科手术、放射治疗等在内的干预性手段也存在继发后续并发症的风险,影响该类人群的长期预后,如生长发育和生活质量等。2014—2022年,国际上一个多学科专家小组通过系统化的文献检索和德尔菲共识法,于2024年制定了首个针对19岁以下儿童和青少年的垂体腺瘤诊断与治疗共识指南。该文就该指南包含的与神经影像学、视觉评估、组织病理学、遗传学、垂体手术和放射治疗相关的建议,以及针对各类型垂体瘤(催乳素瘤、库欣病、巨人症和肢端肥大症、临床无功能腺瘤和促甲状腺激素瘤)的建议要点进行了解读,以期为该类患者的诊治提供建议。Pituitary adenomas are relatively rare in children and adolescents.Due to the lack of high-quality evidence specific to this age group,their diagnosis and treatment pose challenges.In addition to the space-occupying nature of the tumor itself and the abnormal hormone secretion characteristics,interventional measures such as surgical operations and radiotherapy also carry the risk of secondary complications,which affect the long-term prognosis of this group of people,such as growth and development and quality of life.From 2014 to 2022,an international multidisciplinary expert panel,through systematic literature review and the Delphi consensus method,developed the first consensus guideline for the diagnosis and treatment of pituitary adenomas in children and adolescents under 19 years old in 2024.This article interpreted the recommendations in the guideline related to neuroimaging,visual assessment,histopathology,genetics,pituitary surgery,and radiotherapy,as well as the key points of recommendations for various types of pituitary tumors(prolactinomas,Cushing′s disease,acromegaly and gigantism,clinically non-functioning adenomas,and thyrotropinomas),with the aim of providing guidance for the diagnosis and treatment of such patients.

关 键 词：垂体腺瘤 儿童 青少年 共识指南 解读 

分 类 号：R736.4[医药卫生—肿瘤]