Effectiveness of mesenchymal stem cell-derived extracellular vesicles therapy for Parkinson’s disease:A systematic review of preclinical studies  

作　　者：Xue-Song Wang Yue Wang Yan Xu Shan-Rong Zhang Yang Zhang Lu-Lu Peng Nan Wu Jun-Song Ye 

机构地区：[1]Subcenter for Stem Cell Clinical Translation,First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,Jiangxi Province,China [2]School of Rehabilitation Medicine,Gannan Medical University,Ganzhou 341000,Jiangxi Province,China [3]Ganzhou Key Laboratory of Stem Cell and Regenerative Medicine,Gannan Medical University,Ganzhou 341000,Jiangxi Province,China [4]College of Nursing,Gannan Medical University,Ganzhou 341000,Jiangxi Province,China [5]First Clinical Medical College of Gannan Medical University,Gannan Medical University,Ganzhou 341000,Jiangxi Province,China [6]Jiangxi Provincial Key Laboratory of Tissue Engineering,Gannan Medical University,Ganzhou 341000,Jiangxi Province,China [7]Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Ministry of Education,Gannan Medical University,Ganzhou 341000,Jiangxi Province,China

出　　处：《World Journal of Stem Cells》2025年第4期136-149,共14页世界干细胞杂志(英文)

基　　金：Supported by the National Natural Science Foundation of China,No.32060232;and the Natural Science Foundation of Jiangxi Province,No.20212BAB206075.

摘　　要：BACKGROUND Mesenchymal stem cell-derived extracellular vesicles(MSC-EVs)can traverse the blood-brain barrier due to their small size.This characteristic makes them a research hotspot for the treatment of Parkinson’s disease(PD)and is expected to be a potentially revolutionary strategy for treating PD.Despite this,no summary of clinical trial results has been reported.AIM To assess the efficacy and durability of MSC-EVs in treating PD.METHODS Systematic searches were conducted in four electronic databases until June 2024 to collect studies on the use of MSC-EVs for this purpose.Thirteen relevant randomized controlled trials,encompassing 16 experiments,were selected for inclusion.RESULTS Behavioral assessments,including the rotarod and apomorphine turning behavior tests,indicated improvements in motor coordination(P<0.00001);the Pole test and the Wire-hang test showed enhanced limb motor agility and synchronization(P=0.003 and P<0.00001,respectively).Histopathologically,there was a reduction in inflammatory markers such as tumor necrosis factor-αand interleukin-6(P=0.03 and P=0.01,respectively)and an increase in tyrosine hydroxylase-positive cells in the lesion areas(P<0.00001).CONCLUSION MSC-EV therapy for PD is a gradual process,with significant improvements observable more than 2 weeks after administration and lasting at least 8 weeks.This study is the first to demonstrate the efficacy and durability of MSC-EV treatment in PD.

关 键 词：Mesenchymal stem cell Extracellular vesicles EXOSOMES Stem cell therapy Parkinson’s disease Systematic review 

分 类 号：R742.5[医药卫生—神经病学与精神病学]