Dexamethasone intravitreal implant monotherapy in naive patients with macular edema secondary to retinal vein occlusion:long term follow-up retrospective cohort study  

作　　者：Gamze Karataş AkınÇakır Tahsin Uzundede Öznur Aday Ahmet MelihÖzoğuz Mehmet Egemen Karataş AslıKırmacıKabakcı 

机构地区：[1]Department of Ophthalmology,Cemil Taşcıoğlu City Hospital,Istanbul 34384,Türkiye [2]Department of Ophthalmology,Şişli Hamidiye Etfal Training and Research Hospital,Istanbul 34418,Türkiye

出　　处：《International Journal of Ophthalmology(English edition)》2025年第5期876-882,共7页国际眼科杂志(英文版)

摘　　要：AIM:To investigate the efficacy and safety of repeated dexamethasone implants with real-life data in eyes with naive retinal vein occlusion(RVO)with macular edema(ME)at a minimum of 60mo follow-up.METHODS:In this retrospective cohort study,the data about best corrected visual acuity(BCVA),central macular thickness(CMT),serous macular detachment(SMD),hard exudate,hyperreflective foci(HRF),cystoid degeneration,pearl necklace sign,epiretinal membrane(ERM),disorganization of retinal inner layers(DRIL),ellipsoid zone and external limiting membrane(EZ-ELM)integrity,intraocular pressure(IOP)and lens condition were recorded.RESULTS:Thirty-eight eyes of 38 patients were included in the study.Thirteen patients presented with central RVO(CRVO)and 25 with branch RVO(BRVO).The mean follow-up time was 69.9±15.8mo,and the mean number of injections was 7.9±4.0.The mean BCVA gain was 25.0±36 letters,and this difference was statistically significant(P=0.021).The BCVA gain was 19.4±20.4 letters in the CRVO group,and 26.5±38.6 letters in the BRVO group(P=0.763).Besides,21(55.2%)of the patients achieved≥15 letters improvement.At the end of the follow-up period,SMD was not observed in any of the patients(P=0.016).Hard exudate,HRF number were decreased;while DRIL,ERM and EZ-ELM defects were increased but not significantly.CONCLUSION:Intravitreal dexamethasone monotherapy is an effective and safe treatment option for the treatment-naive RVO-ME patients in the long-term follow-up.

关 键 词：DEXAMETHASONE intravitreal naïve retinal vein occlusion macular edema 

分 类 号：R774.1[医药卫生—眼科]