Genotype–microbiome–metabolome associations in early childhood and their link to BMI  

作　　者：Andrea Aparicio Zheng Sun Diane R.Gold Jessica A.Lasky‐Su Augusto A.Litonjua Scott T.Weiss Kathleen Lee‐Sarwar Yang‐Yu Liu 

机构地区：[1]Department of Medicine,Brigham and Women's Hospital and Harvard Medical School,Channing Division of Network Medicine,Boston,Massachusetts,USA [2]Department of Environmental Health,Harvard T.H.Chan School of Public Health,Boston,Massachusetts,USA [3]Division of Pediatric Pulmonary Medicine,Golisano Children's Hospital at Strong,University of Rochester Medical Center,Rochester,New York,USA [4]Division of Allergy and Clinical Immunology,Brigham and Women's Hospital and Harvard Medical School,Boston,Massachusetts,USA [5]Vertex Pharmaceuticals,Boston,Massachusetts,USA [6]Center for Artificial Intelligence and Modeling,The Carl R.Woese Institute for Genomic Biology,University of Illinois at Urbana‐Champaign,Champaign,Illinois,USA

出　　处：《mLife》2024年第4期573-577,共5页微生物(英文)

基　　金：VDAART was funded by U01HL091528 from the National Heart,Lung,and Blood Institute;Additional funding came from NIH(grants K08HL148178,R01HL141826,R01HL108818,and T32HL742742);ECHO(grant OD023268).

摘　　要：Impact statement Through the analysis of data from children aged 6 months to 8 years enrolled in the Vitamin D Antenatal Asthma Reduction Trial(VDAART),significant simultaneous associations were identified between variants in the fragile histidine triad(FHIT)gene,children's body mass index,microbiome features related to obesity,and key lipids and amino acids.These patterns represent evidence of the genotype influence in shaping the host microbiome in developing stages and new potential biomarkers for childhood obesity,insulin resistance,and type 2 diabetes.

关 键 词：vitamin d antenatal asthma reduction genotype influence MICROBIOME METABOLOME lipids amino acidsthese fragile histidine triad fhit genechildrens analysis data GENOTYPE 

分 类 号：R725.6[医药卫生—儿科]