口服新型复合水溶性膳食纤维对超重/肥胖伴轻度高脂血症患者脂代谢影响的随机对照研究  

A Randomized Controlled Study of the Effects of Oral Administration of Novel Complex Water-Soluble Dietary Fiber on Lipid Metabolism in Overweight or Obese Patients with Mild Hyperlipidemia

作　　者：张新胜 吕春健 刘鹿 于志盟 杨荩冉 李丽雅 刘英华 ZHANG Xinsheng;LV Chunjian;LIU Lu;YU Zhimeng;YANG Jinran;LI Liyan;LIU Yinghua(Department of Nutrition,the First Medical Center of PLA General Hospital,Beijing 100853,China;Department of Nutrition,the Fourth Medical Center of PLA General Hospital,Beijing 100048,China)

机构地区：[1]中国人民解放军总医院第一医学中心营养科,北京100853 [2]中国人民解放军总医院第四医学中心营养科,北京100048

出　　处：《中国医药导刊》2025年第3期282-287,共6页Chinese Journal of Medicinal Guide

基　　金：军保委重点专项科研项目(22BJZ20)。

摘　　要：目的:探讨口服新型复合水溶性膳食纤维联合饮食运动干预对超重/肥胖伴轻度高脂血症患者脂代谢及体成分的影响。方法:采用随机对照试验设计,将80例超重/肥胖伴轻度高脂血症患者分为试验组(A组,n=40)和对照组(B组,n=40)。A组接受新型复合水溶性膳食纤维(每日20 g)联合标准化饮食运动干预,B组仅接受饮食运动干预,持续12周。收集受试者一般情况,比较两组营养素摄入情况、体成分分析指标(体脂百分比、体脂重、去脂体重、肌肉重、蛋白质、无机盐、总体水、细胞外液、细胞内液)及血清学指标(AST、ALT、TP、ALB、球蛋白、TBIL、DBIL、IBIL、GGT、ALP、GLU、Crea、BUN、TC、TG、LDL-C、HDL-C、AST/ALT、白/球蛋白比、TC/HDL-C、非-HDL-C)的变化。结果:干预后,A组膳食纤维摄入量高于B组(P<0.05),脂肪摄入量低于B组(P<0.05)。A组基础代谢率(Δ=-7.74 kcal·d^(-1))体脂百分比(Δ=-0.01%)、体脂重(Δ=-0.48 kg)及血脂指标减少量(TCΔ=-0.25 mmol·L^(-1)、LDL-CΔ=-0.09 mmol·L^(-1)、非HDL-CΔ=-0.13 mmol·L^(-1))优于B组(P<0.05)。A组TC/HDL-C比值增加程度低于B组(Δ=0.18 vs 0.36,P<0.05),且未发现肝肾毒性。结论:口服新型复合水溶性膳食纤维联合生活方式干预可有效改善超重/肥胖伴轻度高脂血症患者的体脂分布及脂代谢紊乱。Objective:To evaluate the effects of oral novel composite soluble dietary fiber combined with diet and exercise interven⁃tion on lipid metabolism and body composition in overweight or obese patients with mild hyperlipidemia.Methods:A randomized con⁃trolled trial was conducted with 80 overweight or obese patients with mild hyperlipidemia.Participants were divided into two groups,the intervention group(Group A,n=40)receiving novel composite soluble dietary fiber(20 g/day)plus standardized diet and exercise,and the control group(Group B,n=40)receiving diet and exercise alone for 12 weeks.Collect general information about subjects,Nutrient intake,body composition analysis indexes(body fat percentage,body fat weight,fat removal weight,muscle weight,protein,inorganic salt,total water,extracellular fluid,intracellular fluid)and blood lipid indexes(AST,ALT,TP,ALB,globulin,TBIL,DBIL,IBIL,GGT,ALP,GLU,Crea,BUN,TC,TG,LDL-C,HDL-C,AST/ALT,white/globulin ratio,TC/HDL-C,non-HDL-C)changes were com⁃pared between the two groups.Results:After intervention,Group A showed significantly higher dietary fiber intake(P<0.05)and lower fat intake(P<0.05)compared to Group B.Group A demonstrated greater reductions in basal metabolic rate(Δ=-7.74 kcal·d^(-1)),body fat percentage(Δ=-0.01%),fat mass(Δ=-0.48 kg),and lipid parameters(TCΔ=-0.25 mmol·L^(-1),LDL-CΔ=-0.09 mmol·L^(-1),non-HDL-CΔ=-0.13 mmol·L^(-1),P<0.05).The increase of TC/HDL-C ratio in group A was lower than that in group B(Δ=0.18 vs 0.36,P<0.05),with no adverse effects on liver or kidney function.Conclusion:Oral administration of new composite water-soluble dietary fiber combined with lifestyle intervention can effectively improve the body fat distribution and lipid metabolism disorders in overweight or obe⁃sity patients with mild hyperlipidemia.

关 键 词：水溶性膳食纤维 超重 肥胖 高脂血症 人体成分分析 

分 类 号：R151[医药卫生—营养与食品卫生学] R589.2[医药卫生—公共卫生与预防医学]