[1,2]-Phospha-Brook Rearrangement-Initiated Palladium-Catalyzed Cyclization Reaction of Isocyanides and o-Bromobenzaldehydes:Access to 2H-Isoindole-1-carboxamides and 2H-Isoindole-1-carbonitriles  

作　　者：Binbin Wang Qiushan Gao Huanfeng Jiang Wanqing Wu 

机构地区：[1]Key Laboratory of Functional Molecular Engineering of Guangdong Province,State Key Laboratory of Luminescent Materials and Devices,School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou,Guangdong,510640 China

出　　处：《Chinese Journal of Chemistry》2025年第6期620-626,共7页中国化学(英文版)

基　　金：financially supported by the National Natural Science Foundation of China(22071063);National Youth Talent Support Program,Guangdong Basic and Applied Basic Research Foundation(2021B1515020058 and 2024B1515040027);Guangzhou Science and Technology Projects(2024A04J6248).

摘　　要：Comprehensive Summary Herein,a[1,2]-phospha-Brook rearrangement-initiated palladium-catalyzed cyclization reaction for base-controlled selective synthesis of 2H-isoindole-1-carboxamide and 2H-isoindole-1-carbonitrile derivatives has been described.This strategy features double isocyanide insertion,efficient bond combinations,simple operation and reaction conditions.Mechanistic studies show that the[1,2]-phospha-Brook rearrangement is the key step in this reaction.This protocol offers a novel and concise strategy for the synthesis of 2H-isoindole derivatives.

关 键 词：PALLADIUM-CATALYZED Cyclization[1 2]-Phospha-Brook rearrangement ISOCYANIDES Insertion Heterocycles 

分 类 号：O626[理学—有机化学]