癫痫患儿神经精神共患病的相关因素分析  

Related factors analysis of neuropsychiatric co-morbidities in children with epilepsy

作　　者：张新颖[1] 孙萌[1] 王江娅[1] 程亚颖[1] Zhang Xinying;Sun Meng;Wang Jiangya;Cheng Yaying(Department of Pediatrics,Hebei General Hospital,Shijiazhuang 050051,China)

机构地区：[1]河北省人民医院儿科,石家庄050051

出　　处：《中国小儿急救医学》2025年第3期181-185,共5页Chinese Pediatric Emergency Medicine

基　　金：河北省卫生健康委医学科学研究课题(20190210)。

摘　　要：目的研究癫痫患儿的智能发育、精神行为及社会适应能力状况,分析影响智能发育、精神行为及社会适应能力状况的相关因素。方法随机选取河北省人民医院儿科2017年1月至2022年1月诊治的290例癫痫患儿为研究对象。应用Gesell发育商量表或韦氏智力量表对其智能发育进行综合评估,根据有无智能发育落后分为智能发育落后组(121例)和智能发育正常的对照组(169例),对两组患儿的相关资料进行分析。结果两组患儿病程、癫痫发作频率、癫痫持续状态及抗癫痫用药种数比较差异有统计学意义(P<0.05),年龄、性别、发病年龄、发作形式、发作间期癫痫样放电、热性惊厥史及患病至首次就诊时间比较差异无统计学意义(P>0.05)。多因素Logistic回归分析显示,癫痫发作频率高(OR=0.713,P<0.05)、病程长(OR=0.893,P<0.05)及抗癫痫用药种数多(OR=0.630,P<0.05)是癫痫患儿发生智能发育落后的高危因素。结论癫痫发作频率高、病程长及抗癫痫用药种数多是癫痫患儿智能发育落后的高危因素,应及早加以防治。避免多药联合是目前可调控的因素之一。Objective To study the intellectual development,mental behavior and social adaptability of children with epilepsy,and to analyze the related factors affecting the intellectual development,mental behavior and social adaptability.Methods A total of 290 children with epilepsy diagnosed and treated in the department of pediatrics at Hebei General Hospital from January 2017 to January 2022 were randomly selected as study subjects.The Gesell Developmental Negotiation Scale or Wechsler Intelligence Scale was used to comprehensively assess their intellectual development,and they were divided into the retarded intellectual development group(n=121)and the control group(n=169)with normal intellectual development,according to the presence or absence of retarded intellectual development.Results The differences in disease duration,frequency of epilepsy,status epilepticus,and numbers of antiepileptic drugs between the two groups were statistically significant(all P<0.05),while there were no statistically significant differences in age,gender,age at onset,seizure form,interictal epileptiform discharges,history of febrile convulsions,and the time from onset to initial visit(P>0.05).Multifactorial Logistic regression analysis showed that high seizure frequency(OR=0.713,P<0.05),long duration of illness(OR=0.893,P<0.05),and high number of antiepileptic drugs(OR=0.630,P<0.05)were the high-risk factors for the occurrence of retarded intellectual development in children with epilepsy.Conclusion High frequency of seizures,long duration of the disease and high number of antiepileptic drugs are risk factors for retarded intellectual development in children with epilepsy,and should be prevented and controlled early.Avoidance of multidrug combinations is one of the currently modifiable factors.

关 键 词：癫痫 智能发育落后 神经精神共患病 儿童 相关因素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]