Mechanism of AstragalosideⅣin Treatment of Renal Tubulointerstitial Fibrosis  

作　　者：WANG Xin-ru LUAN Jing-xiang GUO Zhao-an 

机构地区：[1]First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan,250014,China [2]Department of Nephrology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,250014,China

出　　处：《Chinese Journal of Integrative Medicine》2025年第5期474-480,共7页中国结合医学杂志(英文版)

基　　金：Supported by Shandong Natural Science(No.ZR2022LZY005)。

摘　　要：Tubulointerstitial fibrosis(TIF)is one of the key indicators in evaluating the renal function of patients.Mild TIF can cause a vicious cycle of renal tubular glomerular injury and aggravate renal disease.Therefore,studying the mechanisms underlying TIF is essential to identify therapeutic targets,thereby protecting the renal function of patients with timely intervention.AstragalosideⅣ(AS-Ⅳ)is a Chinese medicine component that has been shown to inhibit the occurrence and progression of TIF via multiple pathways.Previous studies have reported that AS-Ⅳprotected against TIF by inhibiting inflammation,autophagy,endoplasmic reticulum stress,macrophages,and transforming growth factor-β1,which laid the foundation for the development of a new preventive and therapeutic option for TIF.

关 键 词：astragalosideⅣ tubulointerstitial fibrosis endoplasmic reticulum stress AUTOPHAGY MACROPHAGES Chinese medicine REVIEW 

分 类 号：R285[医药卫生—中药学]