成骨相关多肽在种植体表面生物功能化改性的研究进展  

The research progress of titanium implant surface biofunctionalized modification with osteogenic peptides

作　　者：刘梦园[1] 吴凯敏 Liu Mengyuan;Wu Kaimin(Oral Research Center,Qingdao Hospital,University of Health and Rehabilitation Sciences(Qingdao Municipal Hospital),Qingdao 266071,China;Department of Stomatology,Navy 971st Hospital,Qingdao 266071,China)

机构地区：[1]康复大学青岛医院(青岛市市立医院)口腔医疗中心,青岛266071 [2]海军第971医院口腔科

出　　处：《口腔颌面修复学杂志》2025年第3期235-240,共6页Chinese Journal of Prosthodontics

摘　　要：钛和钛合金材料具有良好的力学性能和生物相容性,现已被广泛应用于牙科和骨科手术中。开发具有更高成骨能力的生物医用钛种植体,从而实现更好的种植体骨结合,是临床不断提出的要求。种植体表面生物功能化改性是物理化学改性之外的另一种有效促进骨结合的手段。相对于全长蛋白,生物活性片段多肽具有合成方便、特异性高和免疫原性低等特点,已广泛应用于种植体表面改性的研究。本文将对成骨作用多肽在种植体表面的应用加以综述。Due to the good mechanical property and excellent biocompatibility,titanium and its alloys have been widely used as dental implant and replacement of bones.Further improvement is needed to meet clinical demands for biomedical titanium implants with higher osteogenic capacity and tighter osseointegration.Biofunctionalization of titanium implant is another effective method to promote implant osseointegration.Compared with full-length proteins,the use of peptides as bioactive moieties presents advantages of easy synthesis,high specificity and low immunogenicity,and have been used for implant surface modification.In this paper,the application of osteogenic peptides on implant surface are reviewed.

关 键 词：种植体 多肽 功能化改性 骨结合 涂层 

分 类 号：R780.2[医药卫生—口腔医学]