慢性胃炎粘膜内CD_(3)^(+)细胞,S-100^(+)树突状细胞和n NOS表达与幽门螺旋杆菌感染的关系研究  

STUDY OF THE RELATIONSHIP BETWEEN HELICOBACTER PYLORI AND EXPRESSION OF CD3^(+),S-100^(+)DENDRITIC CELLS AND n NOS IN THE MUCOSA OF CHRONIC GASTRITIS

作　　者：武一曼[1] 葛振华[2] 周凡[2] 周维湛[2] 唐福康[2] 王若愚[2] 

机构地区：[1]福建中医学院 [2]福建省中医药研究院,福州350003

出　　处：《中国组织化学与细胞化学杂志》2002年第4期399-402,508,共5页Chinese Journal of Histochemistry and Cytochemistry

基　　金：福建省卫生厅科研基金资助课题(No.96057)

摘　　要：目的　探讨幽门螺旋杆菌 (Hp)与慢性胃炎粘膜内CD3+ 细胞 ,S 10 0 + 树突状细胞和nNOS表达之间的关系。方法　用免疫细胞化学方法 ,检测Hp+ 和Hp 胃炎患者及正常人的胃窦部活检标本。结果　Hp+ 胃炎组胃窦粘膜内CD3+ 细胞和S 10 0 + 树突状细胞数量明显高于Hp-胃炎和正常组 ,且有显著性差异 (P <0 0 1和P <0 0 5 ) ,而nNOS呈高表达 ,与Hp-胃炎组相比有显著性差异 (P <0 0 1)。结论　Hp+ 胃炎患者胃窦粘膜内CD3+ 细胞和S 10 0 + 树突状细胞的增加是机体对Hp的免疫应答 ,而nNOS在Hp+ 胃炎组的高表达可能与Hp感染有密切关系。? Objective To clarify the relationship between the helicobacter pylori (HP) and the CD3+ cells, S-100+ dendritic cells and nNOS in the mucosa of chronic gastritis. Method The biopsy samples of antral mucosa of HP+ and HP- gastritis patients and normal controls were detected by using immunocytochemical method. Result The number of CD3+ cells and S-100+ dendritic cells in the mucosa of the HP+ gastritis group was higher than that of the HP- gastritis group (P<0.01 and P<0.05). The expression of nNOS was also high in HP+ gastritis as compared with that in HP- gastrtis (P<0.01). Conclusion The increased number of CD3+ cells and S-100+ dendritic cells in the mucosa of HP+ gastrtis might be an immunue response to HP. The strong expression of nNOS in the HP+ gastritis group might be closely related to HP infection. 〔

关 键 词：慢性胃炎 Hp CD_(3)^(+)细胞 S-100^(+)树突状细胞 NNOS 免疫细胞化学 

分 类 号：R573.3[医药卫生—消化系统]