韭黄、韭菜、大蒜叶的抗突变作用机理  

Antimutagenic Mechanisms of Hotbed Chives, Fragrant-Flowered Garlic and Garlic Leaves

作　　者：陆敦[1] 印木泉[1] 

机构地区：[1]第二军医大学训练部特殊毒理学教研室,200433

出　　处：《第二军医大学学报》1992年第1期62-65,共4页Academic Journal of Second Military Medical University

摘　　要：应用SOS显色试验研究了韭黄、韭菜、大蒜叶3种蔬菜水溶性提取物的抗突变作用机理。结果表明:这些蔬菜提取物能在大肠杆菌GW1060,GW1104中抑制温度(42℃)诱发的SOS反应,但不能抑制SOS网络开放型菌株GW2707的SOS反应,因此,其抑制SOS反应的机理为在细胞内抑制RecA蛋白酶调控的lexA抑制体的裂解。3种蔬菜提取物去突变试验结果表明,尚有部分在细胞外直接灭活致突物的作用。In the present paper, antimutagenic mechanisms of hotbed chives, fragrant-flowered garlic and garlic leaves were investigated by the SOS Chromotest The results showed that these vegetables could inhibit the SOS respones induced by temperature (42℃) in E coli GW1060 and GW11M (rec 441 (tif)), but they could not act on SOS network gene expression in E. coli GW2707 (lexA::Tn5), so one of their antimutagenic mechanisms is inhibitory effect on cleavage of lexA by RecA protease. Desmutagenic test results indicate that some aqueous extractions of the three vegatables can inactivate mutagens outside cells.

关 键 词：蔬菜 突变 抗突变效应 SOS显色试验 

分 类 号：R730.52[医药卫生—肿瘤]