人肝内胆管细胞癌及癌旁组织中X基因翻译产物的定位  

Localization of X- gene translated product in human cholangiocarci- noma and its peripheral liver tissues

作　　者：胡敏[1] 王文亮[1] 朱新生[1] 

机构地区：[1]第四军医大学病理学教研室

出　　处：《第四军医大学学报》1992年第6期411-413,共3页Journal of the Fourth Military Medical University

摘　　要：人肝内胆管细胞癌较少见,以往其病因及发病机理不明.作者采用抗生物素-生物素-过氧化物酶复合物技术,检测西安地区20例人原发性肝内胆管细胞癌及癌旁组织.首次发现多数病例(17例,85％)有HBV X基因翻译产物——X抗原(HBxAg)表达.其中15例癌组织和16例癌旁肝组织中呈HBxAg阳性反应.提示人肝内胆管细胞癌的发生与HBV感染密切相关,HBxAg在其发病过程中起重要作用.Cholangiocarcinoma of the liver is a rare type of primary hepatoma and its pathogenic mechanism is still unknown. Twenty samples of the cancer and the peripheral tissues of the cancer all taken from Xi'an area were examined for the presence of X-gene product (HBxAg) by using the avidin-biotin-peroxidase complex method. It was found that 17 cases (85%) showed positive response, HBxAg was present in 15 cancer samples and in 16 non -tumor tissue samples. This result suggests that human Cholangiocarcinoma is closely related with infection of HBV and that HBxAg might play an important role in the pathogenesis of Cholangiocarcinoma.

关 键 词：胆管肿瘤 癌 乙型肝炎病毒 X基因 

分 类 号：R735.803[医药卫生—肿瘤]