First Synthesis of 2a-Thiol Ether Analog of Docetaxel  

作　　者：Wei Shuo FANG Ying LIU Qi Cheng FANG 

机构地区：[1]Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050

出　　处：《Chinese Chemical Letters》2002年第8期708-710,共3页中国化学快报(英文版)

基　　金：Financial support from Funding to Outstanding Doctor Thesis Authors of Chinese Universities (Grant No. 199949) is gratefully acknowledged by W. S. Fang.

摘　　要：A 2a-phenylthio ether analog 1c of docetaxel was synthesized for the first time from 10-deacetylbaccatin III 3 via double inversion of C-2 configuration. This compound showed very weak cytotoxicity toward several tumor cell lines.A 2a-phenylthio ether analog 1c of docetaxel was synthesized for the first time from 10-deacetylbaccatin III 3 via double inversion of C-2 configuration. This compound showed very weak cytotoxicity toward several tumor cell lines.

关 键 词：PACLITAXEL DOCETAXEL thiol ether. 

分 类 号：O623[理学—有机化学]