Entry into Major Groups Retaining Taxol via Sinenxan A  

作　　者：Meng ZHANG Da Li YIN Ji Yu GUO Xiao Tian LIANG 

机构地区：[1]Institute of Materia Medica,Chinese Academy of Medical Science&Peking Union Medical College,Beijing 100050

出　　处：《Chinese Chemical Letters》2002年第2期135-138,共4页中国化学快报(英文版)

基　　金：This research work was financially supported by NNSFC.

摘　　要：Compound 1 as a key intermediate of 1, 7, 9-trideoxytaxol was synthesized in ten steps from a biosynthetically available taxane, Sinenxan A. The key steps in the synthesis were deoxygenation at C-14, allylic oxidation at C-13 and construction of the oxetane ring.Compound 1 as a key intermediate of 1, 7, 9-trideoxytaxol was synthesized in ten steps from a biosynthetically available taxane, Sinenxan A. The key steps in the synthesis were deoxygenation at C-14, allylic oxidation at C-13 and construction of the oxetane ring.

关 键 词：TAXOL Sinenxan A deoxygenation. 

分 类 号：R73-36[医药卫生—肿瘤]