基质金属蛋白酶-2与大肠癌浸润转移的关系  

Relationship of expression of matrix metaloproteinases 2 to invasion and metastasis of colorectal cancer

作　　者：陶雅军[1] 陈英杰[1] 任新[1] 温冬青[1] 张朝群[2] 

机构地区：[1]大连大学医学院基础I教研室,辽宁大连116622 [2]大连医科大学病理学教研室,辽宁大连116027

出　　处：《大连医科大学学报》2002年第4期247-249,共3页Journal of Dalian Medical University

摘　　要：[目的 ]探讨基质金属蛋白酶 - 2 (MMP - 2 )表达与大肠癌浸润转移的关系。 [方法 ]采用S -P免疫组织化学染色技术 ,检测 30例大肠腺瘤 ,6 0例大肠癌组织MMP - 2的表达情况。 [结果 ]MMP - 2的表达率在大肠腺瘤中为 2 6 .6 7% ,显著低于大肠癌中的 86 .6 7% (P <0 .0 5 ) ;其表达与大肠癌的Dukes分期、分化程度、淋巴结转移和生存期均密切相关 (P均 <0 .0 5 )。 [结论 ]MMP - 2的检测可以成为临床判断大肠癌的恶性程度。To investingate the role of the expression of matrix metaloproteinases 2 (MMP-2) in invasion and metastasis of colorectal cancer(CRC). The MMP-2 expression was studied immuneohistochemistrically in 30 specimens of colorectal adenoma and 60 specimens of CRC. The expression rates of MMP-2 were 26.67% in colorectal adenoma and 86.67% in CRC, the later was apparently higher than the former( P <0.001). The MMP-2 expression was significantly related to Dukes stage ,cellular dedifferentiation, metastasis of lymph node and poor prognosis. [Conclusion] The detection of expression about MMP-2 may be helpful to judge the malignant behavier of colorectal carcinoma and prognosis of the patient.

关 键 词：基质金属蛋白酶-2 大肠癌 浸润转移 

分 类 号：R735.34[医药卫生—肿瘤]