原发性癫癎高发家族的46个家系调查  

Investigation of high incidence families of primary epilepsy in 46 clans

作　　者：唐嶂龙 唐健 

机构地区：[1]宣城市人民医院,242000

出　　处：《安徽医学》2003年第1期12-13,共2页Anhui Medical Journal

摘　　要：目的　研究原发性癫痫的遗传方式。方法　选自 1987～ 2 0 0 2年的原发性癫痫 960例 ,其中家族中有 2个或 2个以上发病者 46例 ,对其中 7个家族 4个世代 ,3 9个家族 3个世代共 62 9人进行调查。结果　发病 12 9例 ,男74,女 5 5例 ,一级亲属发病 84例 ,占发病总数 2 9.46%,占本级亲属总数的 18.91%;二级亲属发病 3 1例 ,占发病总数的2 4.0 3 %,占本级亲属总数的 9.45 %,三级亲属发病 14例 ,占发病总数的 10 .85 %,占本级亲属总数的 2 .40 %。结论　癫痫存在遗传倾向 ,血缘关系越近发病率越高 。Objective To evaluate the heredity tendencyand pattern of primary epilepsy. Methods 960 cases havebeen discovered from 1987 to 2002, among which 46 patients' families have no less than two cases 629 cases in all. Weare investigated among four generations ofseven clans and three generations of 39 clans. Results 129personns suffered from the diseases, 74 males and 55 females. The first-class relative had 84 patients which occupies 29.46% in all cases and 18.19% in the class. The second-class relative had 31 patients which occupies 29.03% in all cases, and 9.45% in the class. The third-class relative have 14%, which occupies 10.85% in all cases and 2.4% in the class. Conclusion Primaryepilepsy has heredity tendency, closer in consanguinity, higher incidence in the disease. It is multigeneheredity.

关 键 词：原发性癫痫 家系调查 遗传 

分 类 号：R742.1[医药卫生—神经病学与精神病学]