COMT基因多态性与精神分裂症的相关性  

Relationship Between the COMT Locus Polymorphism and Schizophrenia

作　　者：孙祖玥[1] 尉军[1] 刘树铮[1] 

机构地区：[1]吉林大学基因组医学研究中心卫生部放射生物学重点实验室,吉林长春130021

出　　处：《吉林大学学报（医学版）》2003年第1期16-18,共3页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题 (9970 16 5 )

摘　　要：目的 :探讨儿茶酚氧位甲基转移酶 ( COMT)基因多态性与精神分裂症的相关性。方法 :采用限制性片段长度多态性 ( RFLP)分析方法 ,对 1 1 6个中国吉林省汉族精神分裂症核心家庭进行以家族为基础的关联研究 ,检测 COMT位点的两个单个核苷酸多态性 ( SNP1和 SNP2 )与精神分裂症的相关性。结果 :COMT位点的 2个 SNPs传递与未传递等位基因频率分布的差异无显著性 ,但 SNP1位点与精神分裂症阳性症状的关系妄想综合征密切相关。结论 :不支持Objective: To explore the association between polymorphisms for the catechol o methyl transferase (COMT) locus and schizophrenia. Methods:The family based association studies were conducted with restriction fragment length polymorphism (RFLP) analysis to assess the association between polymorphisms for the COMT locus and schizophrenia in 116 Chinese Han population nuclear families consisting of father, mother and offspring suffered from schizophrenia. Results:No significant differences were found in the frequencies of the two SNP markers at the COMT locus. But the SNP 1 was significantly associated with positive symptoms: delusion of observation. Conclusion: The present results did not support the hypothesis that the COMT gene might play an important role in predisposing an individual to a genetic risk for schizophrenia.

关 键 词：儿茶酚氧位甲基转移酶 精神分裂症 遗传学 基因多态性 限制性片段长度多态性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]