Inhibition of regrowth of prostatic glandular cells by epristeride  

爱普列特抑制大鼠前列腺细胞的再生长(英文)

作　　者：钱立晖[1] 王晓麟[1] 屠曾宏[1] 

机构地区：[1]中国科学院上海生命科学研究院上海药物研究所,上海中国200031

出　　处：《Acta Pharmacologica Sinica》2001年第9期847-850,共4页中国药理学报（英文版）

摘　　要：AIM: To evaluate the ability of epristeride to inhibit the prostatic glandular regrowth. METHODS: Normal rats were castrated. Testosterone was injected to induce the regrowth of glandular cells. HE staining was performed. The height of the glandular epithelium and the acinar luminal areas were determined, and dihydrotestosterone ( DHT ) was detected by immunohistochemistry. RESULTS: Both the height and the acinar luminal areas were reduced by 48 % and 55 % in epristeride-treated group compared with control group respectively. The staining of DHT was comparatively strong in the control group. After 30-d of treatment, it turned much weaker. CONCLUSION: The regrowth of glandular cells was inhibited by epristeride via declining of the DHT concentration in the rat prostate.目的:评价爱普列特抑制前列腺细胞重新生长的能力。方法:正常大鼠去势后注射丙酸睾丸酮刺激前列腺重新生长。HE染色进行形态学观察。测量前列腺上皮细胞高度及腺腔面积。免疫组化测定DHT浓度。结果:大鼠口服爱普列特10mg/kg前列腺上皮高度和腺腔面积分别仅为对照组的48％和55％免疫组化表明,大鼠口服爱普列特30天后,DHT浓度显著下降。结论:爱普列特通过降低DHT浓度来抑制前列腺细胞的重新生长。

关 键 词：epristeride PROSTATE CASTRATION IMMUNOHISTOCHEMISTRY 

分 类 号：R96[医药卫生—药理学]