缺血性脑血管病患者血浆P选择素的含量及其临床意义  

The clinical significance and content of soluble P-selection in the patients with ischemic cerebrovascular disease

作　　者：曾丽莉[1] 刘振国[1] 刘建荣[1] 沈介明[1] 陈生弟[1] 

机构地区：[1]上海第二医科大学附属瑞金医院神经内科,200025

出　　处：《临床神经病学杂志》2003年第1期25-27,共3页Journal of Clinical Neurology

摘　　要：目的　探讨缺血性脑血管病 (ICVD)患者血浆P选择素的含量及其临床意义。方法　运用酶联免疫吸附双抗体夹心法对 2 8例ICVD患者、4 5例脑卒中易患者以及 33名健康对照者的血浆中P选择素含量进行测定 ,观察其在动脉硬化期 ,ICVD不同阶段含量变化 ,以及肠溶阿司匹林 (M ASA)干预的影响。结果　ICVD组发病不同时期血浆P选择素含量均明显高于有易患因素的动脉硬化组 (均P <0 .0 5 ) ,后者又明显高于正常对照组 (均P <0 .0 0 1) ;血浆P选择素含量与神经功能缺损程度呈正相关 (r=0 .2 4 13,P <0 .0 5 ) ;服用M ASA的ICVD患者组血浆中可溶性P选择素含量较未用药组明显降低 (P <0 .0 5 )。结论　P选择素含量能反映缺血性脑血管病变的程度 ,可作为ICVD发生的预测指标 ;与ICVD严重程度相关 ;MObjective To investigate the clinical significance and the content of soluble P selection in the patients with ischemic cerebrovascular disease(ICVD)Methods Using the means of an enzyme linked immunosorbent assay,the contents of soluble P selectin (sP selection) were measured in 28 patients with ICVD,45 patients with stroke and 33 health persons.We observed its content changes form atherosclerosis to different stages of ICVD,and the effect of M ASA.Results sP selection in different stages of ICVD group was higher than in the patients with atherosclerosis( P <0.05). the later was higher than the normal control group( P < 0.001 ).There was a linear correlation between the content of soluble sP selection and the degree of ischemic neurological deficit( r =0.2413, P < 0.05 ). Compared with the patients without M ASA, sP selection was significantly decreased in patients of ICVD with M ASA( P <0.05).Conclusion The content of sP selection can reflect the degree of vascular pathological changes,and it may play the role of indicator for ICVD.It is related to the severity degree of ICVD; M ASA can decrease the content of sP selection.

关 键 词：P选择素 动脉硬化 缺血性脑血管病 肠溶阿司匹林 细胞粘附分子 临床意义 

分 类 号：R743[医药卫生—神经病学与精神病学]