组织金属蛋白酶抑制剂-2与大肠癌浸润转移的关系  

The relationship between MMP-2 and infiltration, metastasis of color-ectal cancer

作　　者：陶雅军[1] 陈英杰[1] 任新[1] 温冬青[1] 

机构地区：[1]大连大学医学院基础Ⅰ教研室,大连116622

出　　处：《实用肿瘤学杂志》2003年第1期1-3,共3页Practical Oncology Journal

摘　　要：目的 探讨组织金属蛋白酶抑制剂-2(TIMP-2)表达与大肠癌浸润转移的关系。方法 采用S-P免疫组织化学染色技术,检测30例大肠腺瘤,60例大肠癌组织TIMP-2的表达情况。结果 TIMP-2的表达在大肠腺瘤和大肠癌组织中没有显著性差异(P>0.05);但其表达与大肠癌的Dukes分期、淋巴结转移、远隔脏器转移及生存期均有关(P<0.05)。结论TIMP-2的检测可以成为临床判断大肠癌的恶性程度、转移及预后的重要参考指标。Objective To investigate the role of the expressionof Tissue inhibitor of metalloproteinase-2 (TIMP-2) in invasion andme-tastasis of colorectal cancer( CRC) . Methods The TIMP-2 expression was studied immuneohistochemistrically in 30 specimens of color-ectaladenoma and 60 specimens of CRC. Results No apparent correlation was observed between the expression of TIMP-2 and colorectal adenoma and CRC ( P > 0.05), Significant relationship was observed between low TIMP-2 expression and Dukes stage, metastasis of lymph node anddistant organs and poor prognosis. Conclusion The detection of expression about TIMP-2 may be helpful to judge the malignant behavior, metastasis andprognosis with colorectal carcinoma.

关 键 词：组织金属蛋白酶抑制剂-2 大肠癌 肿瘤浸润 肿瘤转移 

分 类 号：R735.34[医药卫生—肿瘤] R73－37[医药卫生—临床医学]