精神分裂症家系中患病同胞缺陷型及非缺陷型分布的一致性  

Concordance of deficit and non-deficit subtypes in siblings with schizophrenia

作　　者：洪晓虹[1] 许崇涛[1] 王娴贤[1] 梁春莲[1] 肖勃[1] 陈平周[1] 庄希航[1] 卓永宁[1] 

机构地区：[1]汕头大学精神卫生中心,515063

出　　处：《中华精神科杂志》2003年第1期25-27,共3页Chinese Journal of Psychiatry

摘　　要：目的　探讨精神分裂症患病同胞对缺陷型及非缺陷型在家系中分布的一致性。方法收集 51个精神分裂症家系 1 1 1例患者 ,共 70对患病同胞 ,用Kirkpatrick缺陷综合征量表评定精神分裂症患者的缺陷症状 ,并将其划分为缺陷型及非缺陷型。采用同胞对法分析患病同胞缺陷型及非缺陷亚型的一致性。结果　精神分裂症患病同胞对缺陷型及非缺陷型不符合随机分布 ,差异具有显著性(χ2 =1 2 40 ,ν =1 ,P <0 0 0 1 )。结论　精神分裂症患病同胞中缺陷型及非缺陷型的分布具有家族聚集现象。Objective To evaluate the concordance of deficit and non deficit subtypes in affected siblings with schizophrenia Methods There were 111 patients with schizophrenia in 51 families All patients were divided into deficit or non deficit subtype according to the Schedule for the Deficit Syndrome score The concordance of deficit and non deficit subtypes was examined using sib pair method Results The distribution of deficit and non deficit syndromes in sibling pairs of schizophrenic patients differed significantly from chance expectation (χ 2=12 40, ν=1, P <0 001) Conclusion The deficit and non deficit syndrome may be used to define phenotype for genetic study of schizophrenia

关 键 词：精神分裂症 医学遗传学 同胞关系 表型 

分 类 号：R749.3[医药卫生—神经病学与精神病学]