海洛因依赖与多巴胺D_2受体基因的关联分析  

Association study of heroin dependence and dopamine D_2 receptor gene

作　　者：曹莉萍[1] 李涛[1] 刘协和[1] 

机构地区：[1]四川大学华西医院精神科

出　　处：《中华精神科杂志》2003年第1期31-33,共3页Chinese Journal of Psychiatry

基　　金：国家自然科学基金 ( 39876 2 58);四川大学博士点基金( 9957)

摘　　要：目的　探讨海洛因依赖与多巴胺D2 受体基因的相关性。方法　应用聚合酶链反应 限制性片段长度多态性分析技术 ,检测 30 2例海洛因依赖者和 1 77名正常对照者的D2 受体基因 - 1 4 1CIns/Del多态性的基因型和等位基因频率。结果　共检测出三种基因型 :纯合子 - 1 4 1CDel/Del(30 4bp、30 4bp)、杂合子 - 1 4 1CIns/Del(30 4bp、1 60bp、1 4 4bp)、纯合子 - 1 4 1CIns/Ins(1 60bp、1 4 4bp)。海洛因依赖组的 - 1 4 1CIns/Del多态性的基因型频率与对照组的差异无显著性 (χ2 =5 33 ,P =0 0 7) ,但海洛因依赖组 - 1 4 1CDel等位基因频率 (1 6 6 % )高于对照组 (1 1 0 % ;χ2 =5 37,P =0 0 2 )。结论　D2 受体基因 - 1 4Objective To detect the relationship between heroin dependence and dopamine D 2 receptor gene Methods Genotype and allele frequencies of -141C Ins/Del polymorphism of dopamine D 2 receptor gene were examined in 302 heroin dependent subjects and 177 normal controls, using PCR RFLP technique Results No difference in genotype frequencies was observed between heroin dependent subjects and controls (χ 2=5 33, P =0 07) However, a higher frequency of -141C Del allele in heroin dependent subjects was found than in normal controls (16 6% vs 11 0%; χ 2=5 37, P =0 02) Conclusion The results suggest that liability to heroin dependence may be associated with -141C Ins/Del polymorphism of dopamine D 2 receptor gene, with -141C Del allele being a risk factor for heroin dependence

关 键 词：海洛因依赖 多巴胺D2受体 限制性片段长度多态性 等位基因 

分 类 号：R749.61[医药卫生—神经病学与精神病学]