乙醛脱氢酶2与饮酒和HBsAg致肝癌交互作用  

Interaction between polymorphisms of aldehyde dehydrogenase-2 genotypes and drinking habit as well as liver neoplasms caused by HBsAg

作　　者：丁建华[1] 李苏平[1] 吴建中[1] 周建农[1] 高长明[1] 周学富[2] 丁保国[2] 王如鸿 

机构地区：[1]江苏省肿瘤防治研究所流行病研究室,南京210009 [2]江苏省泰兴市卫生防疫站

出　　处：《中国公共卫生》2003年第3期260-262,共3页Chinese Journal of Public Health

基　　金：江苏省 1 999年社会发展基金重点项目资金资助

摘　　要：目的　研究乙醛脱氢酶 - 2 (ALDH2 )基因多态性与饮酒习惯和HBsAg致肝癌的交互作用。 方法　选择88例新发肝癌病人按性别、年龄和居住地进行 1∶1配对流行病学调查。病例和对照均采集静脉血 ,用PCR -RFLP法检测研究对象的ALDH2基因型 ,用ELISA法检测血中乙型肝炎病毒表面抗原 (HBsAg)。 结果　病例组 ( 3 6 40 % )与对照组 ( 3 5 2 2 % )ALDH2变异基因型 (G/L +L/L)的分布频率无显著性差异 ;但HBsAg阳性率病例组 ( 72 73 % )显著高于对照组 ( 2 2 73 % ) ;大量饮酒、HBsAg阳性与ALDH变异基因型的交互作用指数分别为 0 83 2 0和 0 663 4。 结论　乙醛脱氢酶 2变异基因型与大量饮酒和HBsAg阳性致肝癌发生有显著的交互作用。Objective To study the interaction between drinking habit and HBsAg with polymorphisms of aldehyde dehydrogenase-2 (ALDH2) genotypes in liver cancer.Methods A case-control study including 88 cases of newly diagnosed liver cancer and 88 controls matched on sex,age and resident area was carried out ,blood samples from all individuals were collected and tested for ALDH2 genotypes by PCR-RFLP method as well as for HBsAg by ELISA method.Results The frequencies of ALDH2 variant genotypes (G/L+L/L) in cases and controls were 36.40% and 35.22% ,and no difference was found between these two groups.The positive rates of HBsAg between cases and controls showed differences,much higher in cases(72.73%) than those in controls(22.73%).This study showed interactions index of large amount of alcohol consumption and positive rates of HBsAg with ALDH variant genotypes were 0.8320 and 0.6634,respectively.Conclusion The study showed significant interaction between large amount of alcohol consumption and positive rates of HBsAg with ALDH variant genotypes,and revealed a strong relation between polymorphisms of ALDH2 genotypes and heavy alcohol consumption for susceptibility of liver cancer.

关 键 词：肝肿瘤 病例对照研究 乙醛脱氢酶 乙型肝炎病毒表面抗原 酒精 交互作用 

分 类 号：R735.7[医药卫生—肿瘤]