海岛居民营养素摄入量与胃癌发生关系的研究  

THE NUTRITIONAL FACTORS OF GASTRIC CANCER IN THE RESIDENTS OF ISLANDS

作　　者：裘炯良[1] 陈坤[1] 王建跃 张立军 水黎明[1] 

机构地区：[1]浙江大学公共卫生学院流行病教研室,杭州310031 [2]舟山市疾病控制中心,舟山316000

出　　处：《营养学报》2003年第1期23-28,共6页Acta Nutrimenta Sinica

基　　金：卫生部基金项目 ( N o.WK Z- 2 0 0 1- 1- 17)

摘　　要：目的 :　研究海岛地区居民膳食营养素摄入量与胃癌发病的联系。方法 :　采用频数匹配的病例对照研究法 ,随机选择舟山市原发性胃癌新发病例 87例和人群对照 1 1 9例 ,进行有关饮食因素的调查 ,并把各饮食项目折算成 1 6种营养素的日均摄入量后以非条件 Logistic回归法分析其与胃癌发生的关系。结果 :　在调整了非饮食因素和总热能对各项营养素的干扰后 ,蛋白质、饱和脂肪酸、胆固醇、钠等在男性组为胃癌的危险因素 ,在女性组仅钠是胃癌的危险因素 ;维生素 A在男、女性组均为胃癌的保护因素 ,OR值介于 0 .0 1～ 0 .0 9,而维生素 C仅在女性组为胃癌的保护因素。结论 :　高蛋白质、饱和脂肪酸、胆固醇及高盐饮食可能是胃癌的危险因素 ,而维生素A、C可作为胃癌的保护因子 ,另外在胃癌的致病因素上男。Objective: To study the relationship between the nutritional factors and gastric cancer in residents of islands. Methods: A frequency matched design of case control study was used. Included in the study were 87 cases of gastric cancer newly diagnosed in 2001 and 119 controls randomly selected among the residents of Zhoushan Islands. Dietary nutrients intake was estimated using a constructed food frequency questionnaire. 16 nutrients were calculated according to the food composition table and their adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional Logistic regression models. Results: Increased risks of gastric cancer were associated with protein, saturated fat, cholesterol, sodium. An inversed association with the risk of gastric cancer was seen in vitamin A and vitamin C. Conclusion: The role of specific nutrients in the etiology of gastric cancer is high intakes of protein, saturated fat, cholesterol, sodium and poor intakes of vitamin A and C. And there are some differences in etiology of gastric cancer between males and females.

关 键 词：胃癌 营养素 病例对照研究 

分 类 号：R735.2[医药卫生—肿瘤]