COX-2抑制剂celecoxib的合成工艺改进  

Improved synthesis of the COX-2 inhibitor celecoxib

作　　者：唐龙骞[1] 赵彦伟[1] 孟昭力[1] 

机构地区：[1]山东大学药学院,山东济南250012

出　　处：《中国药物化学杂志》2003年第1期44-45,共2页Chinese Journal of Medicinal Chemistry

摘　　要：研究选择性COX 2抑制剂celecoxib的合成工艺。以对苯乙酮为原料 ,经缩合、环合反应得到目标化合物 ,并将二步反应合并为一步进行。产物结构经1H NMR、元素分析确证 ,收率为48 5 %。该法成本低 ,反应条件温和 ,收率高 ,易于生产。To research the suitable synthetic procedure for the celecoxib,a novel nonsteroidal anti-inflammatory drug.It was synthesized from p-methylacetophenone via condensation and cyclization.An improved process for preparing it has been developed in one step.The chemical structure was confirmed by 1H-NMR and elementary analysis,the yield is 48.5%.Low production cost and mild reaction conditions are needed for the preparation,the method also gives good yield.

关 键 词：C0X-2抑制剂 CELECOXIB 合成工艺 改进 药物化学 

分 类 号：TQ464[化学工程—制药化工]