使用手性冠醚的高效液相色谱法研究伯胺类药物的手性分离  

Study on chiral separation of amino drugs by HPLC utilizing crown ethers

作　　者：方骏[1] 夏小庆[1] 吴勇勇[1] 

机构地区：[1]皖南医学院化学教研室,安徽芜湖241001

出　　处：《中国药物化学杂志》2003年第1期48-50,共3页Chinese Journal of Medicinal Chemistry

摘　　要：使用手性柱CrownpakCR(+)的高效液相色谱 (HPLC)法对 11种伯胺类药物进行拆分 ,结果有 10种药物被手性分离。实验结果表明 :柱温下降 ,洗脱时间增大 ,分离度Rs值明显提高 ,而甲醇浓度增大 ,分离度有所减小。Enantiomer separation of eleven drugs having a primary amino group was investigated by high performance liquid chromatography(HPLC)with a chiral Crownpak CR(+)column.Ten out of 11 enantiomers tested were separated by HPLC with Crownpak CR(+).By decreasing the column temperature the elution of the analytes was delayed and enantioselectivity(resolution)was improved,but by increasing the methanol content,the elution of the analytes became more rapid,and the enantioselectivity was decreased.

关 键 词：使用 手性冠醚 高效液相色谱法 研究 伯胺类药物 分析化学 对映异构体 

分 类 号：R914[医药卫生—药物化学]