他克林衍生物及其类似物的研究进展  

Recent advances in the synthesis and pharmacological effects of tacrine derivatives and their analogues

作　　者：李加荣[1] 郭永建[1] 杨新华[1] 李媛艳[1] 

机构地区：[1]北京理工大学化工与材料学院,北京100081

出　　处：《中国药物化学杂志》2003年第1期51-56,共6页Chinese Journal of Medicinal Chemistry

摘　　要：他克林是一个选择性较好但毒副作用明显的乙酰胆碱酯酶抑制剂。为了克服其不足 ,许多他克林衍生物和类似物都已被合成并进行了药理研究。从他克林的芳环、脂环和侧链氨基等 3个方面对他克林衍生物及类似物的合成和药理研究进行综述。Tacrine is a selective acetylcholinesterase(AChE)inhibitor which has serious liver toxicity.In order to overcome its drawbacks,many of tacrine analogues have been synthesized,and the pharmacological activities of some compounds have been studied.The synthesis and pharmacological effects of tacrine derivatives and their analogs were obtained from three main series:aromatic/saturated cyclic derivatives and the tacrine analogues have been systematically reviewed.

关 键 词：他克林衍生物 类似物 研究进展 药物化学 合成 药效 

分 类 号：R914[医药卫生—药物化学] R96[医药卫生—药学]