甲基丙烯酸环氧丙酯对大鼠肝脏谷胱甘肽含量的影响及其可能的生物学意义  

Effects of Glycidyl Methacryiate on Glutathione Content in Rat Liver

作　　者：高惠兰[1] 左瑾[2] 谢大英[1] 李忠生[1] 杨俊保[1] 刘素梅[3] 方福德[2] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所,北京100050 [2]中国医学科学院基础医学研究所 [3]中国医学科学院实验动物所

出　　处：《基础医学与临床》1992年第2期32-35,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金

摘　　要：大鼠一次经胃给予50mg/kg剂量的GMA(Glycidyl Methacrylate),两周后测定显示,其肝脏还原型谷胱甘肽(GSH)含量显著降低,氧化型谷胱甘肽(GSSG)含量明显增加,总谷胱甘肽库(GSH+GSSG)和GSH/GSSG比值亦显著减小,实验还表明,上述改变可能与GMA对不同种类DNA的损伤和基因变异作用密切相关。The new mutagen GMA ( glycidyl methacrylate ) was administrated to rats with single dose of 50mg/kg b.w.and the glutathione content, DNA repair synthesis were determined in two weeks. The results indicated that GMA strongly decreased GSH content,GSH/GSSG,total glutathione pool(i. e. GSH + GSSG ) and increased GSSG content. These changes might be closely related to DNA injury and gene mutation caused by GMA .

关 键 词：谷胱甘肽 GMA DNA损伤 基因变异 

分 类 号：R394.6[医药卫生—医学遗传学]