单纯性肥胖儿童瘦素、胰岛素及其相关性研究  

Study on leptin,insulin and their relationships in simple obese children

作　　者：张彩霞[1] 蒋卓勤[1] 

机构地区：[1]中山大学公共卫生学院医学营养学系

出　　处：《中国公共卫生》2003年第6期657-658,共2页Chinese Journal of Public Health

基　　金：广东省卫生厅基金资助 (A199812 0 )

摘　　要：目的　研究单纯性肥胖儿童瘦素、胰岛素及其相关关系。方法　对筛选出来的 54名肥胖儿童和 60名正常体重儿童进行瘦素、胰岛素、C -肽、血糖水平的测定 ,并进行相关关系的研究。结果　肥胖组儿童瘦素、胰岛素、C -肽、血糖水平高于非肥胖组儿童 ,胰岛素敏感性指数肥胖组儿童低于非肥胖组儿童 ,差异有显著性意义 (P <0 0 5)。瘦素与体质指数、体脂百分比、体脂肪、臀围、胰岛素、C -肽浓度均呈显著正相关 (P <0 0 5) ,与血糖、瘦体重、腰臀围比没有相关性。结论　肥胖儿童存在瘦素抵抗、高胰岛素血症和胰岛素抵抗 ,瘦素与体质指数、胰岛素浓度呈显著正相关。Objective To investigate serum leptin,insulin and their relationships in the simple obese children.Methods Serum Leptin,insulin,C-peptide and fasting blood glucose were measured in 54 obese children and 60 non-obese children.At the same time,the relationship between leptin,obesity and insulin were studied.Results Leptin,insulin,C-peptide,fasting blood glucose were much higher in obese children than in non-obese ones( P <0.05),whereas insulin sensitivity index(IST) was much lower than that in non-bese children.Leptin was significantly correlated with BMI,%BF,BF,hip circumsference,insulin,C-peptide( P <0 05).Leptin was not significantly correlated with blood glucose,LBM,WHR( P >0 05).Conclusions Obese children existed leptin resistance,hyperinsulinaemia and insulin resistance.Leptin was significantly correlated with BMI,insulin.

关 键 词：肥胖 儿童 瘦素 胰岛素 

分 类 号：R153.2[医药卫生—营养与食品卫生学]