SHR大鼠冲动性变化的初步观察  

Impulsivity of Spontaneous Hypertensive Rats

作　　者：徐通[1] 周翊[1] 王强虹[2] 钱燕[1] 张璐定[1] 沈莉[1] 苏渊[1] Sagvolden T 

机构地区：[1]第二军医大学长征医院儿科,200003 [2]重庆西南师范大学教育系 [3]挪威奥斯陆大学医学系神经生理室

出　　处：《中国心理卫生杂志》2003年第5期313-315,共3页Chinese Mental Health Journal

基　　金：挪威政府教育基金 :97- 1 70 4 4 56

摘　　要：目的 :探究注意缺陷多动障碍 (AD HD)动物模型 (自发高血压大鼠 ,SHR)冲动性的变化。方法 :实验在标准Campden连续反应测试箱中进行 ,大鼠禁水 2 2h ,采用长变异间期方案 (长VI,40天 ,变异指数为 180s) ,分析最后 10天稳定曲线的均值。结果 :1、SHR及对照WistarKyoto (WKY)组大鼠按杠获水次数无显著差异。 2、按杠短反应间期 (IRT) :( 1)SHR组的IRT 0 0 ( 0 0 0～ 0 33s)和IRT 0 1( 0 33～ 0 6 6s)均非常明显地高于WKY组 (P <0 0 1)。 ( 2 )整个实验过程的三个相同阶段两组大鼠的短IRT之间均无明显差异。结论 :本实验结果说明SHR大鼠的冲动性要较WKY大鼠强 ,这有助于解释ADHD的发病机理及临床的治疗。Objective: To investigate the impulsivity of SHR (spontaneous hypertensive rat, the animal model of attention deficit/hyperactivity disorder), and compare it with the WKY (Wistar Kyoto Rats).Method:The experiment was carried on in the standard Campden instrument operant chambers, the animals were 22h deprived of water. A long Variable Interval Schedule was used and the stable documents of the last ten days were analyzed.Result:There was no significant difference of the reinforcement between SHR and WKY rats. The short inter-response times (IRTs) of SHR were much higher than that of WKY rats. There was no significant difference of short IRTs of the two groups among the three same segments of the experiment.Conclusion:The impulsivity of SHR is more obvious than WKY rats. It will be helpful for the biological research of ADHD.

关 键 词：注意缺陷多动障碍 儿童精神病 冲动性变化 动物实验 

分 类 号：R749.94[医药卫生—神经病学与精神病学]