视神经-坐骨神经吻合模型中LN及FN的表达  

Laminin and fibronectin in the anastomosed model of optic nerve and sciatic nerve

作　　者：朱益华[1] 朱捷[1] 唐宝丰[1] 徐国兴[1] 童绎[1] 林发森[1] 韩晓丽[1] 

机构地区：[1]中国福建医科大学附属第一医院眼科,350005

出　　处：《国际眼科杂志》2003年第2期16-17,共2页International Eye Science

基　　金：福建省自然科学基金资助;编号 2000F004

摘　　要：目的 研究层粘连蛋白(laminin,LN)及纤维粘连蛋白(fibronectin,FN)在视神经、坐骨神经及视神经-坐骨神经吻合模型中的表达。方法 建立视神经-坐骨神经吻合模型,应用免疫组织化学方法检测LN及FN的表达。结果 在成年大鼠,坐骨神经中有大量的LN及FN的表达,视神经中无LN及FN的表达,在视神经-坐骨神经吻合模型中LN及FN有少最表达。结论 LN及FN有可能促进视神经的再生。Aim To study the expression of Laminin (LN) and Fibronectin (FN) in optic nerve, sciatic nerve and their anastomosed part of adult rats. Methods Anastomosed models of optic nerve and sciatic nerve were set up. LN and FN expressions were shown by im-munohistochemisty. Results In the adult rats, there was a lot of LN and FN expressed in the sciatic nerve, no LN or FN in the optic nerve and a small amount of LN and FN in the anastomosed models. Conclusion LN and FN may play a role in promoting optic nerve regeneration.

关 键 词：视神经-坐骨神经吻合模型 LN FN 层粘连蛋白 纤维粘连蛋白 成年大鼠 免疫组织化学 

分 类 号：R770.2[医药卫生—眼科]