遗传性非息肉病性大肠癌11个家系32例的临床特点与诊治  

Clinical characteristic,diagnosis and therapy of hereditary nonpolyposis colorectal cancer in 32 cases of 11 families

作　　者：陈国富 李嘉根 屈海鸥 王常标 叶玮 

机构地区：[1]温岭市第一人民医院肿瘤科,浙江温岭317500 [2]温岭市第一人民医院肛肠科,浙江温岭317500

出　　处：《中国癌症杂志》2003年第3期240-242,共3页China Oncology

摘　　要：目的 :分析遗传性非息肉病性大肠癌的临床特点及诊治经验。方法 :分析 1 1个家系 32例遗传性非息肉病性大肠癌的诊断、治疗、随访结果 ,分别记录肿瘤发病部位、病理结果等一般情况。结果 :1 1个家系中共有恶性肿瘤 43例 61个肿瘤 ,其中大肠癌 32例 39个肿瘤。 32例中至今共发生异时多原发恶性肿瘤 1 2例 ,占 37 5 % ,其中异时多原发大肠癌 5例 ,占 1 5 6 %。通过先证者对其本人及一级亲属进行随诊检查共发现各类恶性肿瘤 2 8个 ,其中 2 0个 (67 7% )为无明显临床症状者。结论 :本病是一种常染色体显性遗传病 ,本病具有发病年龄早 ,好发于近侧结肠 ,易患异时或同时多原发癌及大肠外恶性肿瘤。在诊治中要作详细病史调查 ,除对先证者进行治疗和随访外 。Purpose:To study the clinic characteristic, diagnosis and therapy of hereditary nonpolypoid colorectal cancer.Methods:We analysed the diagnosis, therapy and follow up of hereditary nonpolypoid colorectal cancer in 32 cases from 11 families by studying the tumour site, pathologic results. Results:There were 43 cancer patients having 61 tumours in 11 families, and 32 cases were intestinal cancer with 39 tumours. In these 32 cases, there were 12 hereditary nonpolypoid colorectal cancer (37.5), and 5 cases were intestinal cancer (15.6). We examined the patients and their direct relatives and found 28 people had various cancer, of which 20 cases without any complaint. Conclusions:Hereditary nonpolypoid colorectal cancer is a dominant hereditary disease, with the characteristic of early flare up,prone to upper colon. They are always non contemporary polygeneous cancer or contemporary polygeneous cancer, and prone to take place outside of colon. So it is important not only for patients to be treated and followed up but also for their relatives to be instructed and followed up. We must study the disease history in details. [

关 键 词：遗传性 非息肉病性 大肠癌 家系 临床特点 诊断 治疗 

分 类 号：R735.34[医药卫生—肿瘤]