大鼠种植型肝癌外周血TNF-α表达水平的变化  

Meaning and alteration of TNF-α expression level of rats with implanted liver tumor

作　　者：邵成伟[1] 王培军[1] 田建明[1] 张火俊[1] 左长京[1] 郝西彦[1] 王敏杰[1] 陈炜[1] 

机构地区：[1]第二军医大学长海医院放射科,上海200433

出　　处：《中国临床医学影像杂志》2003年第4期262-263,283,共3页Journal of China Clinic Medical Imaging

基　　金：国家自然科学基金资助课题;资助号30070233

摘　　要：目的:了解大鼠种植型肝癌生成前后血清TNF-α水平的动态变化及意义。材料与方法:采用直接注射法制作大鼠肝癌动物模型,应用CT或MRI观察大鼠种植型肝癌的影像学特点,应用免疫试剂盒检测大鼠荷瘤前后外周血TNF-α表达水平的变化,并与对照组进行比较。结果:大鼠肝癌种植后7天,种植肝叶均可见类圆形、单发瘤灶影,大小约0.6～0.8cm,CT平扫为低密度,MRI扫描T1WI为低信号。荷瘤大鼠TNF-α表达水平较对照组明显增高,且随肿瘤增大而进一步升高。结论:大鼠种植型肝癌TNF-α表达水平的动态变化与人相似,TNF-α为肝癌疗效评价提供一个有价值指标。Objective:To study the meaning and alteration of TNF-αexpression level of rats with implanted liver tumor.Methods:Direct cancerous ascite injection method was used to make rats liver tumor model.The imaging features of rats with implanted liver tumor were observed with CT or MRI .Serum cytokines TNF-αexpression level was measured using immune kits.The data were compared with those of the control group.Results:Imaging examination showed that single,round tumors were seen in the liver of all these rats seven days later.Low density lesions were seen in pre-contrast scan.Low signal lesions were seen in MRI T 1 WI .TNF-αlevel in rats with liver tumor were higher than those of normal rats and in-creased significantly with increasing of tumor size.Conclusion:TNF-αexpression level of rats with implanted liver tumor is similar to that of human.It is a valuable target to appraise treatment effects of liver tumor.

关 键 词：肝肿瘤 实验性 体层摄影术 X线计算机 磁共振成像 

分 类 号：R735.7[医药卫生—肿瘤] R814.42[医药卫生—临床医学]