GENE EXPRESSION OF NOVEL RETROVIRUS ASSOCIATED WITH HUMAN ACUTE MULOID LEUKEMIA  

作　　者：许晓华 徐荣臻 王世炯 郑树 朱宁希 周旋 

机构地区：[1]Department of Hematology, The Second Affiliated Hospital, Zhejiang University Medical College, Hangzhou 310009 [2]Cancer Institute, Zhejiang University, Hangzhou 310009 [3]Department of Hematology, The Second Affiliated Hospital, Zhejiang University Medical College, Hangzhou 310009,Cancer Institute, Zhejiang University, Hangzhou 310009

出　　处：《Chinese Journal of Cancer Research》2003年第2期98-101,共4页中国癌症研究（英文版）

基　　金：this study was supported by the National Natural Science Foundation of China(No. 39670326).

摘　　要：Objective: To explore the potentiality of retroviral etiology in human acute myeloid leukemia(AML). Methods: The expression of clone 6#11 in leukemic cell samples from 19 AML cases and peripheral blood mononuclear cells (PBMNCs) from 20 controls was studied by means of Northern blot and reversal transcription polymerase chain reaction (RT-PCR). Results: Northern blot and RT-PCR analyses showed that the expression level of clone 6#11 was significantly higher in AML patients than that in control. Conclusion: Northern blot and RT-PCR analyses revealed that the expression of novel retrovirus were associated with acute myeloid leukemia.Objective: To explore the potentiality of retroviral etiology in human acute myeloid leukemia(AML). Methods: The expression of clone 6#11 in leukemic cell samples from 19 AML cases and peripheral blood mononuclear cells (PBMNCs) from 20 controls was studied by means of Northern blot and reversal transcription polymerase chain reaction (RT-PCR). Results: Northern blot and RT-PCR analyses showed that the expression level of clone 6#11 was significantly higher in AML patients than that in control. Conclusion: Northern blot and RT-PCR analyses revealed that the expression of novel retrovirus were associated with acute myeloid leukemia.

关 键 词：Gene expression RETROVIRUS Acute myeloid leukemia 

分 类 号：R733.71[医药卫生—肿瘤]